Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.41 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20696572 | 1.00 | ALDH1A1 (0.44) | ALDH1A1MAPK1CRHBPCRHR2DCLRE1A | |
| SCHEMBL15832277 | 0.83 | CRHBP (0.47) | ALDH1A1MAPK1CRHBPCRHR2DCLRE1A | |
| SCHEMBL5160117 | 0.83 | DCLRE1A (0.43) | ALDH1A1MAPK1DCLRE1ADCLRE1BBACE1 | |
| SCHEMBL455838 | 0.82 | DCLRE1A (0.43) | ALDH1A1MAPK1CRHBPCRHR2DCLRE1A | |
| SCHEMBL18076562 | 0.82 | BACE1 (0.46) | ALDH1A1MAPK1CRHBPCRHR2DCLRE1A | |
| SCHEMBL6772798 | 0.78 | ESR2 (0.47) | ALDH1A1MAPK1DCLRE1ADCLRE1BBACE1 | |
| SCHEMBL6772346 | 0.78 | GAA (0.42) | ALDH1A1MAPK1DCLRE1ADCLRE1BBACE1 | |
| SCHEMBL27403956 | 0.75 | CRHBP (0.56) | ALDH1A1MAPK1CRHBPCRHR2ALOX5 | |
| SCHEMBL8684504 | 0.75 | ADRB2 (0.40) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8536565 | 0.74 | CRHBP (0.39) | ALDH1A1MAPK1CRHBPCRHR2DCLRE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220384735-A1 | PERI-CONDENSED HETEROCYCLIC COMPOUNDS AS MATERIALS FOR ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2022-12-01 | — | — | US | disclosed |
| WO-2021053046-A1 | PERI-CONDENSED HETEROCYCLIC COMPOUNDS AS MATERIALS FOR ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2021-03-25 | — | — | WO | disclosed |
| EP-3271320-B1 | COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND FIBROSIS-RELATED CONDITIONS | VECTUS BIOSYSTEMS LTD (AU) | 2019-10-23 | — | — | EP | disclosed |
| US-10035775-B2 | Compositions for the treatment of fibrosis and fibrosis-related conditions | VECTUS BIOSYSTEMS LIMITED (AU) | 2018-07-31 | — | — | US | disclosed |
| US-20180072682-A1 | COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND FIBROSIS-RELATED CONDITIONS | VECTUS BIOSYSTEMS LIMITED (AU) | 2018-03-15 | — | — | US | disclosed |
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10035775-B2 | Compositions for the treatment of fibrosis and fibrosis-related conditions | MMP1, COL1A1, COL2A1 | ALDH1A1 800/4885MAPK1 2260/4885CRHBP 2573/4885 |
| US-20180072682-A1 | COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND FIBROSIS-RELATED CONDITIONS | MMP1, COL1A1, COL2A1 | ALDH1A1 800/4885MAPK1 2260/4885CRHBP 2573/4885 |
| US-20220384735-A1 | PERI-CONDENSED HETEROCYCLIC COMPOUNDS AS MATERIALS FOR ELECTRONIC DEVICES | KCNH1, NES, KCNC1 | ALDH1A1 828/4885MAPK1 1324/4885CRHBP 1381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.