Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.41 |
| ▸ | USP5 | P45974 | 5/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550173 | 0.82 | MCHR1 (0.50) | DRD2OPRM1MCHR1 | |
| SCHEMBL8549102 | 0.77 | SMN1; SMN2 (0.39) | LMNATP53MAPTPRMT5 | |
| SCHEMBL8551589 | 0.77 | USP5 (0.39) | DRD2LMNAUSP5MCHR1THRA | |
| SCHEMBL8551580 | 0.76 | ALDH1A1 (0.38) | LMNATP53MAPTOPRM1PRMT5 | |
| SCHEMBL8550140 | 0.76 | NAMPT (0.45) | DRD2LMNATP53MAPTPRMT5 | |
| SCHEMBL8553947 | 0.76 | AKR1C3 (0.41) | DRD2LMNATP53MAPT | |
| SCHEMBL8627748 | 0.74 | MEN1 (0.45) | DRD2LMNATP53MAPT | |
| SCHEMBL8549845 | 0.73 | HRH3 (0.49) | DRD2OPRM1MCHR1 | |
| SCHEMBL8551190 | 0.68 | HTR1A (0.64) | DRD2MAPT | |
| SCHEMBL8549874 | 0.67 | MEN1 (0.44) | DRD2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | claimed |
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | disclosed |