Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP5 | P45974 | 5/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | CTSG | P08311 | 1/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550899 | 0.80 | LMNA (0.37) | DRD2LMNARAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL8554951 | 0.80 | LMNA (0.47) | DRD2KDM4ELMNARAB9AKMT2A | |
| SCHEMBL8550173 | 0.77 | MCHR1 (0.50) | DRD2MCHR1ALDH1A1 | |
| SCHEMBL8549848 | 0.77 | DRD2 (0.43) | USP5DRD2THRAVDRMCHR1 | |
| SCHEMBL8549845 | 0.69 | HRH3 (0.49) | DRD2MCHR1 | |
| SCHEMBL8551190 | 0.64 | HTR1A (0.64) | DRD2ALDH1A1 | |
| SCHEMBL8549874 | 0.63 | MEN1 (0.44) | DRD2KDM4ELMNARAB9AKMT2A | |
| SCHEMBL8908861 | 0.62 | SIGMAR1 (0.59) | THRAVDRKDM4EPKMNAMPT | |
| SCHEMBL1789738 | 0.62 | SMN1; SMN2 (0.55) | KDM4EPKMLMNARAB9AKMT2A | |
| SCHEMBL22980539 | 0.61 | CA12 (0.45) | KDM4ELMNARAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | disclosed |