Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18216619 | 0.81 | TDP1 (0.58) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6677228 | 0.81 | RAB9A (0.51) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4859909 | 0.78 | MEN1 (0.64) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL903286 | 0.78 | TDP1 (0.48) | MEN1KMT2AALDH1A1MAPTTDP1 | |
| SCHEMBL15330091 | 0.77 | ERN1 (0.51) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL863443 | 0.76 | HTT (0.57) | KMT2AALDH1A1MAPTLMNATDP1 | |
| SCHEMBL15362097 | 0.76 | PTGDR2 (0.63) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6688354 | 0.76 | ALDH1A1 (0.53) | KMT2AALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL863466 | 0.75 | GPR35 (0.51) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL881185 | 0.75 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1103542-B1 | Process for the preparation of 1,4-diamino-2-methoxymethyl-benzene and its salts and the use of these compounds in dyeing compositions for keratinous fibres | WELLA AG (DE) | 2004-04-28 | — | — | EP | claimed |
| US-20030041392-A1 | Process for making 1,4-diamino-2-methoxymethylbenzene and salts thereof and compositions and methods for dyeing keratin fibers containing same | Wella GmbH (DE) | 2003-03-06 | — | — | US | claimed |
| EP-1103542-A2 | Process for the preparation of 1,4-diamino-2-methoxymethyl-benzene and its salts and the use of these compounds in dyeing compositions for keratinous fibres | Wella Aktiengesellschaft (DE) | 2001-05-30 | — | — | EP | claimed |
| US-9216945-B2 | Methods of synthesizing 2-substituted-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216945-B2 | Methods of synthesizing 2-substituted-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2015-12-22 | — | — | US | disclosed |
| US-8759589-B2 | Methods of synthesizing 2-Methoxymethyl-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2014-06-24 | — | — | US | disclosed |
| US-8759589-B2 | Methods of synthesizing 2-Methoxymethyl-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2014-06-24 | — | — | US | disclosed |
| US-20140081049-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | THE PROCTOR & GAMBLE COMPANY (US) | 2014-03-20 | — | — | US | disclosed |
| US-20140081049-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | THE PROCTOR & GAMBLE COMPANY (US) | 2014-03-20 | — | — | US | disclosed |
| US-20120130128-A1 | Methods of Synthesizing 2-Methoxymethyl-1,4-Benzenediamine | WELLA OPERATIONS US, LLC | 2012-05-24 | — | — | US | disclosed |
| US-20120130128-A1 | Methods of Synthesizing 2-Methoxymethyl-1,4-Benzenediamine | WELLA OPERATIONS US, LLC | 2012-05-24 | — | — | US | disclosed |
| EP-1103542-B1 | Process for the preparation of 1,4-diamino-2-methoxymethyl-benzene and its salts and the use of these compounds in dyeing compositions for keratinous fibres | WELLA AG (DE) | 2004-04-28 | — | — | EP | disclosed |
| US-6648923-B1 | Ready to apply | WELLA AKTIENGESELLSCHAFT (DE) | 2003-11-18 | — | — | US | disclosed |
| US-6558433-B2 | Oxidation hair dye | WELLA AG (DE) | 2003-05-06 | — | — | US | disclosed |
| US-20030041392-A1 | Process for making 1,4-diamino-2-methoxymethylbenzene and salts thereof and compositions and methods for dyeing keratin fibers containing same | Wella GmbH (DE) | 2003-03-06 | — | — | US | disclosed |
| US-20030041392-A1 | Process for making 1,4-diamino-2-methoxymethylbenzene and salts thereof and compositions and methods for dyeing keratin fibers containing same | Wella GmbH (DE) | 2003-03-06 | — | — | US | disclosed |
| EP-1103542-A3 | Process for the preparation of 1,4-diamino-2-methoxymethyl-benzene and its salts and the use of these compounds in dyeing compositions for keratinous fibres | Wella Aktiengesellschaft (DE) | 2001-12-05 | — | — | EP | disclosed |
| JP-2001151739-A | METHOD FOR PRODUCING 1,4-DIAMINO-2-METHOXYMETHYL- BENZENE AND ITS SALT, AND USE OF THESE COMPOUNDS AS DYESTUFF FOR KERATINOUS FIBER | WELLA AG | 2001-06-05 | — | — | JP | disclosed |
| EP-1103542-A2 | Process for the preparation of 1,4-diamino-2-methoxymethyl-benzene and its salts and the use of these compounds in dyeing compositions for keratinous fibres | Wella Aktiengesellschaft (DE) | 2001-05-30 | — | — | EP | disclosed |
| EP-1103542-A2 | Process for the preparation of 1,4-diamino-2-methoxymethyl-benzene and its salts and the use of these compounds in dyeing compositions for keratinous fibres | Wella Aktiengesellschaft (DE) | 2001-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130128-A1 | Methods of Synthesizing 2-Methoxymethyl-1,4-Benzenediamine | HNMT, PNMT, BHMT2 | MEN1 765/4885KMT2A 75/4885ALDH1A1 843/4885 |
| US-20030041392-A1 | Process for making 1,4-diamino-2-methoxymethylbenzene and salts thereof and compositions and methods for dyeing keratin fibers containing same | KRT18, SCNN1B, DDAH1 | MEN1 1222/4885KMT2A 225/4885ALDH1A1 308/4885 |
| US-20140081049-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | TYR, BTD, BRD4 | MEN1 2291/4885KMT2A 626/4885ALDH1A1 837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.