Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524366 | 0.86 | GPR35 (0.55) | GPR35ALDH1A1TSHRTP53HPGD | |
| SCHEMBL4229386 | 0.84 | ALDH1A1 (0.49) | GPR35ALDH1A1TSHRTP53HPGD | |
| SCHEMBL4232672 | 0.83 | ITGA4 (0.49) | GPR35ALDH1A1TSHRTP53HPGD | |
| SCHEMBL4231830 | 0.82 | ALDH1A1 (0.58) | GPR35ALDH1A1TSHRTP53HPGD | |
| SCHEMBL5667642 | 0.81 | ALDH1A1 (0.46) | GPR35ALDH1A1TSHRTP53HPGD | |
| SCHEMBL11317000 | 0.81 | HTT (0.49) | ALDH1A1TSHRHPGDMEN1KMT2A | |
| SCHEMBL792497 | 0.81 | ALDH1A1 (0.56) | ALDH1A1TSHRL3MBTL1MEN1KMT2A | |
| SCHEMBL863443 | 0.81 | HTT (0.57) | ALDH1A1TSHRHPGDGAATHRB | |
| SCHEMBL51277 | 0.80 | GPR35 (0.60) | GPR35ALDH1A1TSHRTP53HPGD | |
| SCHEMBL791991 | 0.80 | HTT (0.44) | ALDH1A1TSHRHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101216468-B | 2-methoxymethyl-4-aminophenol and its impurity highly effective liquid phase chromatography analytical method | SHANGHAI CHEMICAL REAGENT RES INST | 2012-04-18 | — | — | CN | claimed |
| CN-101216468-A | 2-methoxymethyl-4-aminophenol and its impurity highly effective liquid phase chromatography analytical method | SHANGHAI CHEMICAL REAGENT RES (CN) | 2008-07-09 | — | — | CN | claimed |
| EP-1103542-B1 | Process for the preparation of 1,4-diamino-2-methoxymethyl-benzene and its salts and the use of these compounds in dyeing compositions for keratinous fibres | WELLA AG (DE) | 2004-04-28 | — | — | EP | claimed |
| US-20030041392-A1 | Process for making 1,4-diamino-2-methoxymethylbenzene and salts thereof and compositions and methods for dyeing keratin fibers containing same | Wella GmbH (DE) | 2003-03-06 | — | — | US | claimed |
| EP-1103542-A2 | Process for the preparation of 1,4-diamino-2-methoxymethyl-benzene and its salts and the use of these compounds in dyeing compositions for keratinous fibres | Wella Aktiengesellschaft (DE) | 2001-05-30 | — | — | EP | claimed |
| US-9216945-B2 | Methods of synthesizing 2-substituted-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216945-B2 | Methods of synthesizing 2-substituted-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2015-12-22 | — | — | US | disclosed |
| US-8759589-B2 | Methods of synthesizing 2-Methoxymethyl-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2014-06-24 | — | — | US | disclosed |
| US-8759589-B2 | Methods of synthesizing 2-Methoxymethyl-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2014-06-24 | — | — | US | disclosed |
| US-20140081049-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | THE PROCTOR & GAMBLE COMPANY (US) | 2014-03-20 | — | — | US | disclosed |
| US-20140081049-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | THE PROCTOR & GAMBLE COMPANY (US) | 2014-03-20 | — | — | US | disclosed |
| US-20120130128-A1 | Methods of Synthesizing 2-Methoxymethyl-1,4-Benzenediamine | WELLA OPERATIONS US, LLC | 2012-05-24 | — | — | US | disclosed |
| US-6648923-B1 | Ready to apply | WELLA AKTIENGESELLSCHAFT (DE) | 2003-11-18 | — | — | US | disclosed |
| US-6558433-B2 | Oxidation hair dye | WELLA AG (DE) | 2003-05-06 | — | — | US | disclosed |
| US-20030041392-A1 | Process for making 1,4-diamino-2-methoxymethylbenzene and salts thereof and compositions and methods for dyeing keratin fibers containing same | Wella GmbH (DE) | 2003-03-06 | — | — | US | disclosed |
| US-20030041392-A1 | Process for making 1,4-diamino-2-methoxymethylbenzene and salts thereof and compositions and methods for dyeing keratin fibers containing same | Wella GmbH (DE) | 2003-03-06 | — | — | US | disclosed |
| EP-1103542-A3 | Process for the preparation of 1,4-diamino-2-methoxymethyl-benzene and its salts and the use of these compounds in dyeing compositions for keratinous fibres | Wella Aktiengesellschaft (DE) | 2001-12-05 | — | — | EP | disclosed |
| JP-2001151739-A | METHOD FOR PRODUCING 1,4-DIAMINO-2-METHOXYMETHYL- BENZENE AND ITS SALT, AND USE OF THESE COMPOUNDS AS DYESTUFF FOR KERATINOUS FIBER | WELLA AG | 2001-06-05 | — | — | JP | disclosed |
| EP-1103542-A2 | Process for the preparation of 1,4-diamino-2-methoxymethyl-benzene and its salts and the use of these compounds in dyeing compositions for keratinous fibres | Wella Aktiengesellschaft (DE) | 2001-05-30 | — | — | EP | disclosed |
| EP-1103542-A2 | Process for the preparation of 1,4-diamino-2-methoxymethyl-benzene and its salts and the use of these compounds in dyeing compositions for keratinous fibres | Wella Aktiengesellschaft (DE) | 2001-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130128-A1 | Methods of Synthesizing 2-Methoxymethyl-1,4-Benzenediamine | HNMT, PNMT, BHMT2 | GPR35 3801/4885ALDH1A1 843/4885TSHR 4314/4885 |
| US-20030041392-A1 | Process for making 1,4-diamino-2-methoxymethylbenzene and salts thereof and compositions and methods for dyeing keratin fibers containing same | KRT18, SCNN1B, DDAH1 | GPR35 4157/4885ALDH1A1 308/4885TSHR 4501/4885 |
| US-20140081049-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | TYR, BTD, BRD4 | GPR35 4113/4885ALDH1A1 837/4885TSHR 3127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.