Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635870 | 0.88 | KCNJ6 (0.39) | NR1H3PDK1 | |
| SCHEMBL8634221 | 0.86 | SIRT2 (0.34) | SIRT2CYP11B1CYP11B2NR1H2NR1H3 | |
| SCHEMBL8635629 | 0.85 | FLT1 (0.36) | RXRARXRBRXRGSLC9A1 | |
| SCHEMBL8635192 | 0.84 | RXRA (0.35) | RXRARXRBRXRGSLC9A1 | |
| SCHEMBL8635012 | 0.84 | NSD2 (0.36) | RXRARXRBRXRGSLC9A1 | |
| SCHEMBL7764080 | 0.84 | SLC9A1 (0.56) | SLC9A1 | |
| SCHEMBL8634267 | 0.82 | KEAP1 (0.41) | RXRARXRBRXRGPDK1PDK2 | |
| SCHEMBL8635329 | 0.82 | SLC9A1 (0.35) | RXRARXRBRXRGSLC9A1 | |
| SCHEMBL8635732 | 0.81 | KCNJ6 (0.38) | CYP11B1CYP11B2 | |
| SCHEMBL8635768 | 0.81 | ALDH1A1 (0.37) | SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |