Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.36 |
| ▸ | P2RY4 known ✓ | P51582 | 1/20 | 0.33 |
| ▸ | P2RY6 known ✓ | Q15077 | 1/20 | 0.33 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.33 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | RAD51 | Q06609 | 8/20 | 0.39 |
| ▸ | DUSP5 | Q16690 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LTA | P01374 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29683607 | 1.00 | PLCG1 (0.45) | PLCG1TDP1LMNARAD51DUSP5 | |
| SCHEMBL29683608 | 1.00 | PLCG1 (0.45) | PLCG1TDP1LMNARAD51DUSP5 | |
| SCHEMBL28557572 | 0.88 | PLCG1 (0.47) | PLCG1TDP1LMNARAD51DUSP5 | |
| SCHEMBL29425559 | 0.84 | RAD51 (0.46) | PLCG1TDP1LMNARAD51DUSP5 | |
| SCHEMBL2996003 | 0.84 | RAD51 (0.46) | PLCG1TDP1LMNARAD51DUSP5 | |
| SCHEMBL10452311 | 0.82 | TDP1 (0.62) | PLCG1TDP1LMNARAD51KDM4E | |
| Water SCHEMBL29837428 | 0.82 | RAD51 (0.49) | PLCG1TDP1LMNARAD51DUSP5 | |
| Water SCHEMBL4017540 | 0.82 | RAD51 (0.49) | PLCG1TDP1LMNARAD51DUSP5 | |
| SCHEMBL5728771 | 0.78 | PLCG1 (0.69) | PLCG1TDP1LMNAKMT2APOLB | |
| SCHEMBL867702 | 0.78 | PLCG1 (0.44) | PLCG1TDP1LMNAHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117753217-A | Anti-pollution polyamide reverse osmosis membrane containing amphoteric ions and preparation method and application thereof | 万华化学集团股份有限公司 | 2024-03-26 | — | — | CN | claimed |
| US-8969616-B2 | Process for preparation of isosulfan blue | APICORE US LLC (US) | 2015-03-03 | — | — | US | claimed |
| US-20130310600-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2013-11-21 | — | — | US | claimed |
| US-7662992-B2 | Process for preparation of isosulfan blue | APICORE, LLC (US) | 2010-02-16 | — | — | US | claimed |
| US-20080293963-A1 | PROCESS FOR PREPARATION ISOSULFAN BLUE | APICORE, LLC (US) | 2008-11-27 | — | — | US | claimed |
| WO-2008140564-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2008-11-20 | — | — | WO | claimed |
| US-20080281127-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2008-11-13 | — | — | US | claimed |
| CN-117753217-A | Anti-pollution polyamide reverse osmosis membrane containing amphoteric ions and preparation method and application thereof | 万华化学集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| US-20200347013-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE US LLC (US) | 2020-11-05 | — | — | US | disclosed |
| US-10752580-B2 | Process for preparation of isosulfan blue | APICORE US LLC (US) | 2020-08-25 | — | — | US | disclosed |
| US-10723745-B2 | Isosulfan blue, its crystalline form and process for preparation thereof | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2020-07-28 | — | — | US | disclosed |
| US-10626086-B2 | Process for the preparation of isosulfan blue | APICORE US LLC (US) | 2020-04-21 | — | — | US | disclosed |
| US-10590071-B2 | Process for the preparation of isosulfan blue | APICORE US LLC (US) | 2020-03-17 | — | — | US | disclosed |
| US-20130310600-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2013-11-21 | — | — | US | disclosed |
| US-20120078007-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2012-03-29 | — | — | US | disclosed |
| US-20100094044-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2010-04-15 | — | — | US | disclosed |
| US-7662992-B2 | Process for preparation of isosulfan blue | APICORE, LLC (US) | 2010-02-16 | — | — | US | disclosed |
| US-20080293963-A1 | PROCESS FOR PREPARATION ISOSULFAN BLUE | APICORE, LLC (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2008140564-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2008-11-20 | — | — | WO | disclosed |
| US-20080281127-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100094044-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | SI, MPST, STS | THRB 3354/4885P2RY4 1888/4885P2RY6 1568/4885 |
| US-20200347013-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | SI, STS, MPST | THRB 3217/4885P2RY4 2127/4885P2RY6 2019/4885 |
| US-10752580-B2 | Process for preparation of isosulfan blue | SI, STS, MPST | THRB 3217/4885P2RY4 2127/4885P2RY6 2019/4885 |
| US-10626086-B2 | Process for the preparation of isosulfan blue | SI, STS, MPST | THRB 3415/4885P2RY4 2270/4885P2RY6 1888/4885 |
| US-20120078007-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | SI, MPST, STS | THRB 3354/4885P2RY4 1888/4885P2RY6 1568/4885 |
| US-20080293963-A1 | PROCESS FOR PREPARATION ISOSULFAN BLUE | SI, STS, MPST | THRB 3412/4885P2RY4 2047/4885P2RY6 1473/4885 |
| US-20130310600-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | SI, MPST, STS | THRB 3354/4885P2RY4 1888/4885P2RY6 1568/4885 |
| US-10590071-B2 | Process for the preparation of isosulfan blue | SI, STS, MPST | THRB 3415/4885P2RY4 2270/4885P2RY6 1888/4885 |
| US-10723745-B2 | Isosulfan blue, its crystalline form and process for preparation thereof | SI, IK, RPS4Y1 | THRB 3701/4885P2RY4 2706/4885P2RY6 3741/4885 |
| US-20080281127-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | SI, MPST, STS | THRB 3354/4885P2RY4 1888/4885P2RY6 1568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.