Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29683547 | 1.00 | PLCG1 (0.44) | PLCG1TDP1LMNAVCAM1ALDH1A1 | |
| SCHEMBL28557572 | 0.82 | PLCG1 (0.47) | PLCG1TDP1LMNAALDH1A1MEN1 | |
| SCHEMBL31244570 | 0.81 | VCAM1 (0.41) | TDP1LMNAVCAM1ALDH1A1HSD17B10 | |
| SCHEMBL21491267 | 0.81 | LMNA (0.51) | TDP1LMNAVCAM1ALDH1A1ERN1 | |
| SCHEMBL5807669 | 0.81 | VCAM1 (0.61) | LMNAVCAM1ALDH1A1 | |
| SCHEMBL867183 | 0.81 | VCAM1 (0.41) | TDP1LMNAVCAM1ALDH1A1HSD17B10 | |
| SCHEMBL867703 | 0.79 | VCAM1 (0.40) | TDP1LMNAVCAM1ALDH1A1HSD17B10 | |
| SCHEMBL29683608 | 0.78 | PLCG1 (0.45) | PLCG1TDP1LMNAALDH1A1MEN1 | |
| SCHEMBL29683607 | 0.78 | PLCG1 (0.45) | PLCG1TDP1LMNAALDH1A1MEN1 | |
| SCHEMBL867589 | 0.78 | PLCG1 (0.45) | PLCG1TDP1LMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200347013-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE US LLC (US) | 2020-11-05 | — | — | US | claimed |
| US-20180057454-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE US LLC (US) | 2018-03-01 | — | — | US | claimed |
| US-20160221936-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE US LLC (US) | 2016-08-04 | — | — | US | claimed |
| US-9353050-B2 | Process for preparation of isosulfan blue | APICORE US LLC (US) | 2016-05-31 | — | — | US | claimed |
| US-8969616-B2 | Process for preparation of isosulfan blue | APICORE US LLC (US) | 2015-03-03 | — | — | US | claimed |
| US-20130310600-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2013-11-21 | — | — | US | claimed |
| US-20120078007-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2012-03-29 | — | — | US | claimed |
| US-20100094044-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2010-04-15 | — | — | US | claimed |
| US-7662992-B2 | Process for preparation of isosulfan blue | APICORE, LLC (US) | 2010-02-16 | — | — | US | claimed |
| US-20080293963-A1 | PROCESS FOR PREPARATION ISOSULFAN BLUE | APICORE, LLC (US) | 2008-11-27 | — | — | US | claimed |
| WO-2008140564-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2008-11-20 | — | — | WO | claimed |
| US-20080281127-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2008-11-13 | — | — | US | claimed |
| US-20200347013-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE US LLC (US) | 2020-11-05 | — | — | US | disclosed |
| US-10752580-B2 | Process for preparation of isosulfan blue | APICORE US LLC (US) | 2020-08-25 | — | — | US | disclosed |
| US-10626086-B2 | Process for the preparation of isosulfan blue | APICORE US LLC (US) | 2020-04-21 | — | — | US | disclosed |
| US-10590071-B2 | Process for the preparation of isosulfan blue | APICORE US LLC (US) | 2020-03-17 | — | — | US | disclosed |
| US-7662992-B2 | Process for preparation of isosulfan blue | APICORE, LLC (US) | 2010-02-16 | — | — | US | disclosed |
| US-20080293963-A1 | PROCESS FOR PREPARATION ISOSULFAN BLUE | APICORE, LLC (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2008140564-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2008-11-20 | — | — | WO | disclosed |
| US-20080281127-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | APICORE, LLC (US) | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100094044-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | SI, MPST, STS | PLCG1 3145/4885TDP1 4474/4885LMNA 3619/4885 |
| US-20200347013-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | SI, STS, MPST | PLCG1 3457/4885TDP1 4363/4885LMNA 3413/4885 |
| US-10752580-B2 | Process for preparation of isosulfan blue | SI, STS, MPST | PLCG1 3457/4885TDP1 4363/4885LMNA 3413/4885 |
| US-10626086-B2 | Process for the preparation of isosulfan blue | SI, STS, MPST | PLCG1 3351/4885TDP1 4526/4885LMNA 3452/4885 |
| US-20120078007-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | SI, MPST, STS | PLCG1 3145/4885TDP1 4474/4885LMNA 3619/4885 |
| US-20160221936-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | SI, STS, MPST | PLCG1 3457/4885TDP1 4363/4885LMNA 3413/4885 |
| US-20080293963-A1 | PROCESS FOR PREPARATION ISOSULFAN BLUE | SI, STS, MPST | PLCG1 3374/4885TDP1 4507/4885LMNA 3626/4885 |
| US-20130310600-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | SI, MPST, STS | PLCG1 3145/4885TDP1 4474/4885LMNA 3619/4885 |
| US-20180057454-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | SI, STS, MPST | PLCG1 3457/4885TDP1 4363/4885LMNA 3413/4885 |
| US-10590071-B2 | Process for the preparation of isosulfan blue | SI, STS, MPST | PLCG1 3351/4885TDP1 4526/4885LMNA 3452/4885 |
| US-20080281127-A1 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE | SI, MPST, STS | PLCG1 3145/4885TDP1 4474/4885LMNA 3619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.