Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 4/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 13/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.71 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 4/20 | 0.56 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.53 |
| ▸ | AR | P10275 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL871152 | 0.91 | HIF1A (0.76) | HIF1ALMNANFKB1PMP22TSHR | |
| SCHEMBL8750472 | 0.88 | HIF1A (0.72) | HIF1ALMNANFKB1PMP22TSHR | |
| Prednisolone Hemisuccinate SCHEMBL871872 | 0.85 | HIF1A (1.00) | HIF1ALMNANFKB1PMP22TSHR | |
| Prednisolone Hemisuccinate SCHEMBL122046 | 0.85 | HIF1A (1.00) | HIF1ALMNANFKB1PMP22TSHR | |
| SCHEMBL770501 | 0.84 | HIF1A (0.72) | HIF1ALMNANFKB1PMP22TSHR | |
| SCHEMBL31723329 | 0.84 | HIF1A (0.69) | HIF1ALMNANFKB1SMN1; SMN2MAPT | |
| SCHEMBL1938519 | 0.84 | HIF1A (0.69) | HIF1ALMNANFKB1SMN1; SMN2MAPT | |
| Hydrocortisone Hemisuccinate Anhydrous SCHEMBL3684419 | 0.83 | HIF1A (1.00) | HIF1ALMNANFKB1PMP22TSHR | |
| Hydrocortisone Hemisuccinate Anhydrous SCHEMBL29506633 | 0.83 | HIF1A (1.00) | HIF1ALMNANFKB1PMP22TSHR | |
| Hydrocortisone Hemisuccinate Anhydrous SCHEMBL93508 | 0.83 | HIF1A (1.00) | HIF1ALMNANFKB1PMP22TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735469-A2 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF MULTIPLE VACCINES | ALZA Corporation (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005103303-A2 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF MULTIPLE VACCINES | ALZA CORPORATION (US) | 2005-11-03 | — | — | WO | disclosed |