Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959009 | 0.89 | PLA2G2A (0.41) | PLA2G2AKMT2AMEN1TP53TSHR | |
| SCHEMBL2470436 | 0.84 | MAPT (0.45) | PLA2G2AKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL340217 | 0.83 | PLA2G2A (0.56) | PLA2G2AKMT2AMEN1LCKFYN | |
| SCHEMBL28529167 | 0.82 | PLA2G2A (0.67) | PLA2G2AKMT2AMEN1PKMTP53 | |
| SCHEMBL8959016 | 0.81 | PLA2G2A (0.54) | PLA2G2AKMT2AMEN1LCKFYN | |
| SCHEMBL18876765 | 0.79 | PLA2G2A (0.60) | PLA2G2AKMT2AMEN1LCKFYN | |
| SCHEMBL18887941 | 0.77 | PLA2G2A (0.61) | PLA2G2AKMT2AMEN1LCKFYN | |
| SCHEMBL5583897 | 0.76 | CA12 (0.48) | TP53TSHRALDH1A1L3MBTL1PABPC1 | |
| SCHEMBL11505191 | 0.75 | ALDH1A1 (0.60) | KMT2AMEN1TSHRPLA2G4BALDH1A1 | |
| SCHEMBL3077835 | 0.75 | PLA2G2A (0.80) | PLA2G2AKMT2ATP53TSHRPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666837-B1 | DEPOLYMERIZATION OF SUBSTANTIALLY AMORPHOUS POLYESTERS | EASTMAN CHEM CO (US) | 1997-01-02 | — | — | EP | disclosed |
| EP-0666837-A1 | DEPOLYMERIZATION OF SUBSTANTIALLY AMORPHOUS POLYESTERS. | EASTMAN CHEM CO (US) | 1995-08-16 | — | — | EP | disclosed |
| EP-0505473-B1 | ESTER HYDROLYSIS AND DEPOLYMERIZATION OF POLYESTER AND POLYCARBONATE POLYMERS | EASTMAN KODAK CO (US) | 1994-07-20 | — | — | EP | disclosed |
| US-5328982-A | Forming glycols and diacids by contacting with methanol or glycol, aprotic acid and alkoxide or hydroxide | EASTMAN CHEMICAL COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| WO-1994010121-A1 | DEPOLYMERIZATION OF SUBSTANTIALLY AMORPHOUS POLYESTERS | EASTMAN CHEMICAL COMPANY (US) | 1994-05-11 | — | — | WO | disclosed |
| EP-0505473-A1 | ESTER HYDROLYSIS AND DEPOLYMERIZATION OF POLYESTER AND POLYCARBONATE POLYMERS. | EASTMAN KODAK CO (US) | 1992-09-30 | — | — | EP | disclosed |
| US-5045122-A | Alcohol or glycol, aprotic solvent, alkoxide or hydroxide | EASTMAN KODAK COMPANY (US) | 1991-09-03 | — | — | US | disclosed |
| WO-1991009004-A1 | ESTER HYDROLYSIS AND DEPOLYMERIZATION OF POLYESTER AND POLYCARBONATE POLYMERS | EASTMAN KODAK COMPANY (US) | 1991-06-27 | — | — | WO | disclosed |