Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.33 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8746147 | 0.89 | PLA2G2A (0.53) | PLA2G2AKMT2ATP53TSHRALDH1A1 | |
| SCHEMBL2470436 | 0.83 | MAPT (0.45) | PLA2G2AF11KMT2AALDH1A1LMNA | |
| SCHEMBL5583897 | 0.75 | CA12 (0.48) | TP53TSHRGMNNALDH1A1LMNA | |
| Potassium Ion SCHEMBL28924336 | 0.75 | PLA2G2A (0.56) | PLA2G2ATP53TSHRL3MBTL1 | |
| Potassium Ion SCHEMBL28923723 | 0.72 | PLA2G2A (0.66) | PLA2G2ATP53TSHR | |
| Potassium Ion SCHEMBL28630928 | 0.72 | PLA2G2A (0.66) | PLA2G2ATP53TSHR | |
| SCHEMBL340217 | 0.71 | PLA2G2A (0.56) | PLA2G2AKMT2ATP53TSHRGMNN | |
| SCHEMBL11505191 | 0.71 | ALDH1A1 (0.60) | KMT2ATSHRALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4559053 | 0.71 | PLA2G2A (0.34) | PLA2G2AKMT2AALDH1A1LMNAMAPK1 | |
| SCHEMBL11680920 | 0.71 | MAPT (0.66) | KMT2AALDH1A1SMN1; SMN2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673313-A4 | — | — | 1995-11-08 | — | — | EP | claimed |
| EP-0673313-A1 | COPOLYESTER PRIMED BIAXIALLY ORIENTED COPOLYESTER FILM | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-27 | — | — | EP | claimed |
| WO-1994013479-A1 | COPOLYESTER PRIMED BIAXIALLY ORIENTED COPOLYESTER FILM | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-06-23 | — | — | WO | claimed |
| EP-0691369-A1 | Primer coating for polymeric film | Hoechst Diafoil GmbH (DE) | 1996-01-10 | — | — | EP | disclosed |