Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 2/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SGK1 | O00141 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 2/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628709 | 0.90 | ERBB2 (0.40) | MEN1KMT2ATDP1LMNAPOLB | |
| SCHEMBL8634594 | 0.89 | FFAR4 (0.39) | MEN1KMT2ATDP1HTTLMNA | |
| SCHEMBL8631571 | 0.83 | KMO (0.47) | MEN1KMT2ATDP1KMOPTGES2 | |
| SCHEMBL8629094 | 0.82 | ERBB2 (0.40) | MEN1KMT2ATDP1LMNAPOLB | |
| SCHEMBL8632682 | 0.82 | KDM1A (0.46) | MEN1KMT2AHTTLMNAPOLB | |
| SCHEMBL8627699 | 0.81 | MAPK14 (0.40) | MEN1KMT2ATDP1LMNASGK1 | |
| SCHEMBL8634847 | 0.81 | NAT1 (0.46) | MEN1KMT2ALMNAACLYPGR | |
| SCHEMBL8635286 | 0.80 | NAT1 (0.44) | MEN1KMT2ATDP1HTTLMNA | |
| SCHEMBL8629227 | 0.79 | ALDH1A1 (0.43) | MEN1KMT2AHTTLMNAPOLB | |
| SCHEMBL8628728 | 0.78 | CCR2 (0.39) | MEN1KMT2ATDP1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772597-A1 | 3,4-SUBSTITUTED PYRAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003385-A1 | 3,4-SUBSTITUTED PYRAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |