Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGF1 known ✓ | P05230 | 9/20 | 0.69 |
| ▸ | ST6GAL1 | P15907 | 1/20 | 0.82 |
| ▸ | HPSE | Q9Y251 | 12/20 | 0.69 |
| ▸ | CDC25A | P30304 | 2/20 | 0.69 |
| ▸ | POLA1 | P09884 | 1/20 | 0.69 |
| ▸ | FGF2 | P09038 | 8/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | INPP5D | Q92835 | 1/20 | 0.64 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.64 |
| ▸ | VDR | P11473 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8902302 | 1.00 | ST6GAL1 (0.82) | ST6GAL1HPSEFGF1CDC25APOLA1 | |
| SCHEMBL13347854 | 0.91 | VDR (0.76) | ST6GAL1HPSEFGF1CDC25APOLA1 | |
| SCHEMBL17124639 | 0.91 | VDR (0.76) | ST6GAL1HPSEFGF1CDC25APOLA1 | |
| SCHEMBL13311422 | 0.91 | VDR (0.76) | ST6GAL1HPSEFGF1CDC25APOLA1 | |
| SCHEMBL25063600 | 0.90 | ABCC4 (0.78) | ST6GAL1HPSECDC25APOLA1CYP2D6 | |
| SCHEMBL8903512 | 0.90 | ABCC4 (0.78) | ST6GAL1HPSECDC25APOLA1CYP2D6 | |
| SCHEMBL8902867 | 0.90 | ABCC4 (0.78) | ST6GAL1HPSECDC25APOLA1CYP2D6 | |
| SCHEMBL23594716 | 0.90 | ABCC4 (0.78) | ST6GAL1HPSECDC25APOLA1CYP2D6 | |
| Ammonia Solution, Strong SCHEMBL30074798 | 0.89 | ABCC4 (0.76) | ST6GAL1HPSECDC25APOLA1CYP2D6 | |
| SCHEMBL18195977 | 0.87 | CDC25A (0.65) | ST6GAL1HPSEFGF1CDC25APOLA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610180-A | TOCOPHEROL AND CHOLESTEROL DERIVATIVES, CYTOPROTECTIVE AGENTS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1997-03-11 | — | — | US | disclosed |
| US-5336485-A | Administering cholestane phthalates, succinates or sulfates before administering tacrine | CENTER FOR INNOVATIVE TECHNOLOGY (US) | 1994-08-09 | — | — | US | disclosed |
| US-5198432-A | Cytoprotective agents | CENTER FOR INNOVATIVE TECHNOLOGY (US) | 1993-03-30 | — | — | US | disclosed |