Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 5/20 | 0.32 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.31 |
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710245 | 0.86 | S1PR3 (0.38) | GAACA2S1PR3ALDH1A1LMNA | |
| SCHEMBL6928648 | 0.86 | ALDH1A1 (0.39) | GAACA2S1PR3SERPINE1HSD17B10 | |
| SCHEMBL8470113 | 0.86 | ALDH1A1 (0.39) | GAACA2S1PR3SERPINE1HSD17B10 | |
| SCHEMBL9476993 | 0.86 | GAA (0.38) | GAACA2S1PR3KDM4EALDH1A1 | |
| SCHEMBL6686085 | 0.82 | TSHR (0.43) | GAAS1PR3HSD17B10KDM4EALDH1A1 | |
| SCHEMBL28144411 | 0.79 | CA2 (0.38) | GAACA2S1PR3SERPINE1HSD17B10 | |
| SCHEMBL6684905 | 0.77 | LMNA (0.44) | GAACA2S1PR3KDM4EALDH1A1 | |
| SCHEMBL29208594 | 0.74 | LCK (0.34) | GAAS1PR3SERPINE1HSD17B10KDM4E | |
| SCHEMBL28560537 | 0.73 | HSD17B10 (0.47) | CA2S1PR3HSD17B10KDM4EALDH1A1 | |
| SCHEMBL28444369 | 0.72 | ALDH1A1 (0.49) | GAACA2S1PR3SERPINE1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665801-A | High molecular weight polyester flame retardant and process for preparing the same | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 1997-09-09 | — | — | US | claimed |
| US-5665801-A | High molecular weight polyester flame retardant and process for preparing the same | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 1997-09-09 | — | — | US | disclosed |