Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025454 | 0.78 | CA12 (0.34) | PDE5AALDH1A1SMN1; SMN2GPR84KDM4E | |
| SCHEMBL9025514 | 0.76 | PDE4A (0.39) | ALDH1A1SMN1; SMN2KDM4ENPC1PKM | |
| SCHEMBL9026008 | 0.75 | PKM (0.38) | GPR84PKMSYK | |
| SCHEMBL9026859 | 0.74 | ADRA2A (0.45) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL9025089 | 0.74 | KDM4E (0.41) | ALDH1A1SMN1; SMN2HPGDGPR84KDM4E | |
| SCHEMBL9025520 | 0.74 | METAP2 (0.38) | ALDH1A1HPGDGPR84KDM4EGAA | |
| SCHEMBL9032018 | 0.73 | DHFR (0.39) | ALDH1A1SMN1; SMN2HPGDKDM4EGAA | |
| SCHEMBL9026336 | 0.73 | CYP11B2 (0.47) | ALDH1A1SMN1; SMN2KDM4EGAAHSD17B10 | |
| SCHEMBL9024896 | 0.73 | MYB (0.36) | GPR84NPC1RAB9ALMNA | |
| SCHEMBL9025568 | 0.73 | METAP2 (0.39) | ADORA2AALDH1A1GPR84KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |