Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 4/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680848 | 0.86 | KCNE1 (0.46) | KCNE1KCNQ1ABCB1L3MBTL1GAA | |
| SCHEMBL9680855 | 0.85 | KCNE1 (0.47) | KCNE1KCNQ1ABCC9LMNA | |
| SCHEMBL9682025 | 0.85 | LMNA (0.34) | KCNE1KCNQ1ABCB1L3MBTL1ABCC9 | |
| SCHEMBL9193747 | 0.82 | TYK2 (0.36) | ABCC9 | |
| SCHEMBL9680937 | 0.82 | ABCC9 (0.40) | KCNE1KCNQ1ALDH1A1L3MBTL1GAA | |
| SCHEMBL9193528 | 0.82 | ABCB1 (0.52) | KCNE1KCNQ1ABCB1ABCC9LMNA | |
| SCHEMBL9681478 | 0.80 | ALOX5 (0.40) | L3MBTL1ABCC9 | |
| SCHEMBL9680959 | 0.78 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1ABCC9 | |
| SCHEMBL9127063 | 0.76 | IGF1R (0.39) | IDO1ABCC9 | |
| SCHEMBL9199681 | 0.72 | TRPV1 (0.38) | ALDH1A1L3MBTL1TNKSGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0406656-B1 | Chroman derivatives | MERCK PATENT GMBH (DE) | 1995-01-11 | — | — | EP | disclosed |
| US-5112839-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-05-12 | — | — | US | disclosed |
| EP-0406656-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-01-09 | — | — | EP | disclosed |