Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.32 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680848 | 0.84 | KCNE1 (0.46) | ABCC9KDM4EGAAL3MBTL1KCNE1 | |
| SCHEMBL9682025 | 0.83 | LMNA (0.34) | ABCC9KDM4ELMNAL3MBTL1KCNE1 | |
| SCHEMBL9680855 | 0.83 | KCNE1 (0.47) | ABCC9LMNAHTTKCNE1KCNQ1 | |
| SCHEMBL9192059 | 0.82 | KCNE1 (0.43) | ABCC9GAALMNAALDH1A1L3MBTL1 | |
| SCHEMBL9193747 | 0.80 | TYK2 (0.36) | ABCC9 | |
| SCHEMBL9193528 | 0.80 | ABCB1 (0.52) | ABCC9KDM4EKMT2ALMNAMEN1 | |
| SCHEMBL9198494 | 0.79 | ABCC9 (0.44) | ABCC9KMT2AMAPTLMNAHTT | |
| SCHEMBL9681478 | 0.78 | ALOX5 (0.40) | ABCC9L3MBTL1 | |
| SCHEMBL9197886 | 0.78 | ABCC9 (0.42) | ABCC9KMT2AMAPTAKR1B1LMNA | |
| SCHEMBL9680959 | 0.76 | ALDH1A1 (0.41) | ABCC9KDM4EKMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112839-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-05-12 | — | — | US | disclosed |
| EP-0406656-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-01-09 | — | — | EP | disclosed |