Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 1/20 | 0.47 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.47 |
| ▸ | ABCC9 | O60706 | 14/20 | 0.40 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.39 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | CACNA1E | Q15878 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680848 | 0.87 | KCNE1 (0.46) | KCNE1KCNQ1ABCC9 | |
| SCHEMBL9682025 | 0.86 | LMNA (0.34) | KCNE1KCNQ1ABCC9LMNA | |
| SCHEMBL9192059 | 0.85 | KCNE1 (0.43) | KCNE1KCNQ1ABCC9LMNA | |
| SCHEMBL9193528 | 0.83 | ABCB1 (0.52) | KCNE1KCNQ1ABCC9LMNA | |
| SCHEMBL9680937 | 0.83 | ABCC9 (0.40) | KCNE1KCNQ1ABCC9LMNAHTT | |
| SCHEMBL9193747 | 0.83 | TYK2 (0.36) | ABCC9 | |
| SCHEMBL9681478 | 0.81 | ALOX5 (0.40) | ABCC9 | |
| SCHEMBL9680959 | 0.79 | ALDH1A1 (0.41) | ABCC9TP53 | |
| SCHEMBL9127063 | 0.77 | IGF1R (0.39) | ABCC9 | |
| SCHEMBL9194242 | 0.73 | TP53 (0.46) | KCNE1KCNQ1ABCC9LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112839-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-05-12 | — | — | US | disclosed |
| EP-0406656-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-01-09 | — | — | EP | disclosed |