Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL41971 | 0.91 | MAPT (0.42) | EPHX2MAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28109965 | 0.89 | GPR3 (0.42) | EPHX2MAPTSCN5ANISCHALDH1A1 | |
| SCHEMBL28046390 | 0.89 | MAPT (0.41) | EPHX2MAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28513358 | 0.89 | MAPT (0.41) | EPHX2MAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28780452 | 0.86 | EPHX2 (0.50) | EPHX2FAAHMAPTMMP2MMP9 | |
| SCHEMBL28175586 | 0.84 | MAPT (0.42) | EPHX2MAPTNISCHALDH1A1MEN1 | |
| SCHEMBL921934 | 0.83 | CETP (0.43) | MAPTSCN9AALDH1A1MEN1KMT2A | |
| SCHEMBL533257 | 0.83 | KIF11 (0.47) | EPHX2MAPTSCN5ANISCHKIF11 | |
| SCHEMBL29154791 | 0.83 | MAPT (0.37) | EPHX2MAPTNISCHALDH1A1MEN1 | |
| SCHEMBL6573034 | 0.83 | KIF11 (0.47) | EPHX2MAPTSCN5ANISCHKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183278-B1 | Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component | MEIJI SEIKA KAISHA, LTD. (JP) | 2007-02-27 | — | — | US | claimed |
| EP-1660439-A2 | ARYL AND HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Transtech Pharma, Inc. (US) | 2006-05-31 | — | — | EP | claimed |
| US-20050059705-A1 | Aryl and heteroaryl compounds, compositions, and methods of use | VTVX HOLDINGS I LLC | 2005-03-17 | — | — | US | claimed |
| WO-2005014533-A2 | ARYL AND HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | TRANSTECH PHARMA, INC. (US) | 2005-02-17 | — | — | WO | claimed |
| EP-1482931-A2 | MONO- AND BICYCLIC AZOLE DERIVATIVES THAT INHIBIT THE INTERACTION OF LIGANDS WITH RAGE | Transtech Pharma, Inc. (US) | 2004-12-08 | — | — | EP | claimed |
| US-20040082542-A1 | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents | VTV THERAPEUTICS LLC | 2004-04-29 | — | — | US | claimed |
| WO-2003075921-A2 | MONO- AND BICYCLIC AZOLE DERIVATIVES THAT INHIBIT THE INTERACTION OF LIGANDS WITH RAGE | TRANSTECH PHARMA, INC. (US) | 2003-09-18 | — | — | WO | claimed |
| EP-1134214-A1 | PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | MEIJI SEIKA KAISHA LTD. (JP) | 2001-09-19 | — | — | EP | claimed |
| US-5338742-A | Nematicidal use of 4-aralkylpyridines | DOWELANCO (US) | 1994-08-16 | — | — | US | claimed |
| EP-0556377-A4 | NEMATICIDAL USE OF 4-ARALKYLPYRIDINES | DOWELANCO (US) | 1994-05-18 | — | — | EP | claimed |
| EP-0556377-A1 | NEMATICIDAL USE OF 4-ARALKYLPYRIDINES | DOWELANCO (US) | 1993-08-25 | — | — | EP | claimed |
| WO-1993004579-A1 | NEMATICIDAL USE OF 4-ARALKYLPYRIDINES | DOWELANCO (US) | 1993-03-18 | — | — | WO | claimed |
| CN-111630031-B | Process for producing quinolin-4 (1H) -one derivative | 日本化药株式会社 | 2024-03-12 | — | — | CN | disclosed |
| CN-114569552-A | Anti-malarial compositions and uses thereof | 斯克利普斯研究院 | 2022-06-03 | — | — | CN | disclosed |
| US-11267787-B2 | Method for producing quinolin-4(1H)-one derivative | NIPPON KAYAKU CO., LTD (JP) | 2022-03-08 | — | — | US | disclosed |
| US-20210070710-A1 | METHOD FOR PRODUCING QUINOLIN-4(1H)-ONE DERIVATIVE | NIPPON KAYAKU CO., LTD. (JP) | 2021-03-11 | — | — | US | disclosed |
| US-20010039287-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | PHARMACIA CORPORATION | 2001-11-08 | — | — | US | disclosed |
| EP-1134214-A1 | PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | MEIJI SEIKA KAISHA LTD. (JP) | 2001-09-19 | — | — | EP | disclosed |
| US-20010014688-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | BARTA THOMAS E (US) | 2001-08-16 | — | — | US | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11267787-B2 | Method for producing quinolin-4(1H)-one derivative | NQO2, AKR7A2, KEAP1 | EPHX2 1198/4885FAAH 255/4885MAPT 3421/4885 |
| US-20040082542-A1 | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents | AGER, S100A4, S100B | EPHX2 1168/4885FAAH 3525/4885MAPT 406/4885 |
| US-20050059705-A1 | Aryl and heteroaryl compounds, compositions, and methods of use | TFPI, F3, F2 | EPHX2 147/4885FAAH 279/4885MAPT 4777/4885 |
| US-20210070710-A1 | METHOD FOR PRODUCING QUINOLIN-4(1H)-ONE DERIVATIVE | NQO2, AKR7A2, KEAP1 | EPHX2 1198/4885FAAH 255/4885MAPT 3421/4885 |
| US-20010039287-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | MMP13, MMP9, MMP10 | EPHX2 1067/4885FAAH 914/4885MAPT 2312/4885 |
| US-20010014688-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | MMP13, MMP9, MMP10 | EPHX2 1067/4885FAAH 914/4885MAPT 2312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.