SCHEMBL921358

SCHEMBL921358

N#Cc1ccc(F)c(C=O)c1

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RAD51 Q06609 1/20 0.39
ERN1 O75460 2/20 0.38
P4HB P07237 3/20 0.38
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
KIF11 P52732 1/20 0.36
HSD17B14 Q9BPX1 1/20 0.35
ACLY P53396 1/20 0.35
EGLN2 Q96KS0 2/20 0.35
TRPV4 Q9HBA0 1/20 0.34
GAA P10253 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29956520 1.00 RAD51 (0.39) RAD51ERN1P4HBCA1CA2
SCHEMBL29642158 0.96 RAD51 (0.40) RAD51ERN1P4HBCA1CA2
SCHEMBL29956507 0.84 RAD51 (0.42) RAD51ERN1P4HBCA1CA2
SCHEMBL124629 0.84 RAD51 (0.42) RAD51ERN1P4HBCA1CA2
SCHEMBL15777270 0.81 CTSL (0.36) RAD51ERN1P4HBCA1CA2
SCHEMBL1477364 0.81 CYP11B1 (0.40) ERN1
SCHEMBL23407049 0.80 ERN1 (0.38) ERN1CA1CA2
SCHEMBL2693856 0.80 KIF11 (0.36) RAD51P4HBCA2KIF11HSD17B14
SCHEMBL16956501 0.80 P4HB (0.38) RAD51P4HBCA2KIF11HSD17B14
SCHEMBL7195384 0.78 RAD51 (0.40) RAD51CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 281 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024126771-A1 PROCESS FOR PREPARING (Z)-3-(2-(5-BROMO-1H-INDOL-3-YL)-2-CYANOVINYL)-4-METHOXYBENZONITRILE EVEXTA BIO (FR) 2024-06-20 WO claimed
EP-1546150-B1 PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES AMURA THERAPEUTICS LTD (GB) 2009-03-04 EP claimed
US-20060100431-A1 Biologically active compounds AMURA THERAPEUTICS LIMITED (GB) 2006-05-11 US claimed
EP-1546150-A1 BIOLOGICALLY ACTIVE COMPOUNDS Amura Therapeutics Limited (GB) 2005-06-29 EP claimed
WO-2004007501-A1 BIOLOGICALLY ACTIVE COMPOUNDS AMURA THERAPEUTICS LIMITED (GB) 2004-01-22 WO claimed
EP-4720065-A1 PRMT5 INHIBITORS AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-04-08 EP disclosed
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed
CN-115720578-B And tricyclic derivatives, preparation method and medical application thereof 深圳信立泰药业股份有限公司 2025-06-13 CN disclosed
WO-2024245412-A1 PRMT5 INHIBITORS AND USES THEREOF INSILICO MEDICINE IP LIMITED (CN) 2024-12-05 WO disclosed
CN-118359638-A Compound serving as RET kinase inhibitor and preparation method and application thereof 苏州朗睿生物医药有限公司 2024-07-19 CN disclosed
WO-2024124287-A1 COMPOUNDS FOR TREATING VIRAL INFECTION THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) 2024-06-20 WO disclosed
WO-2024126771-A1 PROCESS FOR PREPARING (Z)-3-(2-(5-BROMO-1H-INDOL-3-YL)-2-CYANOVINYL)-4-METHOXYBENZONITRILE EVEXTA BIO (FR) 2024-06-20 WO disclosed
WO-2001002377-A1 TELOMERASE INHIBITORS AND METHODS OF THEIR USE GERON CORPORATION (US) 2001-01-11 WO disclosed
WO-2000071512-A1 INHIBITORS OF FACTOR Xa COR THERAPEUTICS, INC. (US) 2000-11-30 WO disclosed
WO-2000026210-A1 THROMBIN INHIBITORS MERCK & CO., INC. (US) 2000-05-11 WO disclosed
WO-2000026211-A1 THROMBIN INHIBITORS MERCK & CO., INC. (US) 2000-05-11 WO disclosed
WO-1999054284-A1 ANTHRANILIC ACID DERIVATIVES AS INHIBITORS OF THE CGMP-PHOSPHODIESTERASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-10-28 WO disclosed
WO-1999024395-A1 COMPOUNDS WHICH INHIBIT TRYPTASE ACTIVITY ARRAY BIOPHARMA, INC. (US) 1999-05-20 WO disclosed
US-5340833-A Antiarthritic, antiinflammatory, antitumor agents EISAI CO., LTD. (JP) 1994-08-23 US disclosed
EP-0568289-A2 Benzothiophenes and thienothiophenes and related compounds useful, for example, as urokinase inhibitors Eisai Co., Ltd. (JP) 1993-11-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 RAD51 3924/4885ERN1 1140/4885P4HB 4480/4885
US-20060100431-A1 Biologically active compounds SOST, CTSK, CTSS RAD51 1587/4885ERN1 2464/4885P4HB 952/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.