Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MPO | P05164 | 2/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | PPIA | P62937 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL837843 | 0.78 | BACE1 (0.39) | TAAR1RAB9AKMT2AMEN1MAPK8 | |
| SCHEMBL836280 | 0.77 | MAPK8 (0.40) | KMT2AMPOMEN1MAPK8SMN1; SMN2 | |
| SCHEMBL28923083 | 0.76 | LMNA (0.55) | LMNARAB9AKMT2AALDH1A1MAPK1 | |
| SCHEMBL641851 | 0.76 | PKM (0.50) | TAAR1LMNARAB9AKMT2AALDH1A1 | |
| SCHEMBL5259490 | 0.76 | CTBP2 (0.43) | TAAR1KMT2AALDH1A1MEN1MAPK8 | |
| SCHEMBL10397132 | 0.76 | PYCR1 (0.40) | LMNAKMT2AMEN1NPC1 | |
| SCHEMBL1520469 | 0.75 | TAAR1 (0.50) | TAAR1LMNARAB9AALDH1A1IDO1 | |
| SCHEMBL835822 | 0.74 | P2RX7 (0.38) | TAAR1LMNARAB9AKMT2AALDH1A1 | |
| SCHEMBL19980269 | 0.74 | MAPK8 (0.47) | TAAR1LMNARAB9AKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL213754 | 0.73 | IDO1 (0.48) | TAAR1LMNARAB9AKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194382-B1 | PYRAZOLE DERIVATIVES AS SGC STIMULATORS | CYCLERION THERAPEUTICS INC (US) | 2021-09-08 | — | — | EP | disclosed |
| EP-3194382-B1 | PYRAZOLE DERIVATIVES AS SGC STIMULATORS | CYCLERION THERAPEUTICS INC (US) | 2021-09-08 | — | — | EP | disclosed |
| US-20210221793-A1 | PYRAZOLE DERIVATIVES AS SGC STIMULATORS | CYCLERION THERAPEUTICS, INC. | 2021-07-22 | — | — | US | disclosed |
| US-20210221793-A1 | PYRAZOLE DERIVATIVES AS SGC STIMULATORS | CYCLERION THERAPEUTICS, INC. | 2021-07-22 | — | — | US | disclosed |
| US-10844064-B2 | sGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2020-11-24 | — | — | US | disclosed |
| US-10844064-B2 | sGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2020-11-24 | — | — | US | disclosed |
| CN-107223125-B | SGC stimulant | 赛科理音医疗有限公司 | 2019-09-27 | — | — | CN | disclosed |
| US-20190284168-A1 | PYRAZOLE DERIVATIES AS SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC | 2019-09-19 | — | — | US | disclosed |
| US-20190284168-A1 | PYRAZOLE DERIVATIES AS SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC | 2019-09-19 | — | — | US | disclosed |
| US-20190031641-A1 | PYRAZOLE DERIVATIVES AS SGC STIMULATORS | CYCLERION THERAPEUTICS, INC. | 2019-01-31 | — | — | US | disclosed |
| WO-2016044441-A1 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016044447-A1 | PYRAZOLE DERIVATIVES AS SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-03-24 | — | — | WO | disclosed |
| CN-102993084-B | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA | 2015-05-20 | — | — | CN | disclosed |
| EP-2646438-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | Merck Patent GmbH (DE) | 2013-10-09 | — | — | EP | disclosed |
| US-20130245355-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3 B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2013-09-19 | — | — | US | disclosed |
| CN-103228657-A | 3-heteroaryl-substituted pyrrolo [2,3-b ] pyridine derivatives as PDK1 inhibitors | MERCK PATENT GMBH | 2013-07-31 | — | — | CN | disclosed |
| CN-102993084-A | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA | 2013-03-27 | — | — | CN | disclosed |
| CN-101001846-B | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA | 2012-11-07 | — | — | CN | disclosed |
| WO-2012072200-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2012-06-07 | — | — | WO | disclosed |
| CN-101001846-A | Novel alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA (CH) | 2007-07-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210221793-A1 | PYRAZOLE DERIVATIVES AS SGC STIMULATORS | PTGIS, GMPS, NOS3 | TAAR1 2223/4885LMNA 4353/4885RAB9A 2653/4885 |
| US-20190284168-A1 | PYRAZOLE DERIVATIES AS SGC STIMULATORS | PTGIS, GMPS, NOS3 | TAAR1 2464/4885LMNA 4316/4885RAB9A 2574/4885 |
| US-20130245355-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3 B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | PDK1, PDK2, PDK3 | TAAR1 4133/4885LMNA 3634/4885RAB9A 1359/4885 |
| US-10844064-B2 | sGC stimulators | GUCY1B1, GUCY1A1, PRKG1 | TAAR1 2199/4885LMNA 4107/4885RAB9A 745/4885 |
| US-20190031641-A1 | PYRAZOLE DERIVATIVES AS SGC STIMULATORS | PTGIS, GMPS, NOS3 | TAAR1 2223/4885LMNA 4353/4885RAB9A 2653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.