Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Methylene Chloride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.31 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.31 |
| ▸ | CACNA1B known ✓ | Q00975 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Chloride SCHEMBL153756 | 0.96 | CYP2C9 (0.33) | CYP2C9HPGDMAPK1HSD17B10CYP1A2 | |
| Methyl Alcohol SCHEMBL946877 | 0.89 | ALDH1A1 (0.35) | CYP2C9HPGDMAPK1HSD17B10CYP1A2 | |
| Methylene Chloride SCHEMBL187626 | 0.89 | ALDH1A1 (0.36) | CYP2C9HPGDMAPK1HSD17B10CYP1A2 | |
| Acetonitrile SCHEMBL5210744 | 0.88 | — | — | |
| Methylene Chloride SCHEMBL10795300 | 0.86 | KDM4E (0.30) | MAPK1ALDH1A1KDM4EMEN1POLB | |
| Alcohol SCHEMBL946131 | 0.86 | ALDH1A1 (0.43) | CYP2C9HPGDMAPK1HSD17B10CYP1A2 | |
| Methylene Chloride SCHEMBL15348142 | 0.85 | ALDH1A1 (0.33) | ALDH1A1 | |
| Methylene Chloride SCHEMBL14696854 | 0.85 | LMNA (0.35) | ALDH1A1MAPTHTT | |
| Methylene Chloride SCHEMBL9555746 | 0.85 | ALDH1A1 (0.33) | ALDH1A1 | |
| Chloromethane SCHEMBL375766 | 0.85 | CYP2C9 (0.35) | CYP2C9HPGDMAPK1HSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102759598-A | Quality detection method for 29-componnet stagnation dissipation powder as Tibetan medicinal composition and preparations thereof | SHANDONG ARURA PHARMACEUTICAL RES & DEV CO LTD | 2012-10-31 | — | — | CN | claimed |
| CN-102749401-A | Quality inspection method of traditional Chinese medicine composition twenty-five-ingredient lung disease preparation | SHANDONG ARURA PHARMACEUTICAL RES & DEV CO LTD | 2012-10-24 | — | — | CN | claimed |
| CN-115792075-B | Detection method of 4' -monophosphoryl lipid A compound | 江苏瑞科生物技术股份有限公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-115792075-A | Detection method of 4' -monophosphoryl lipid A compound | 江苏瑞科生物技术股份有限公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-102759598-B | Quality detection method for 29-componnet stagnation dissipation powder as Tibetan medicinal composition and preparations thereof | SHANDONG ARURA PHARMACEUTICAL RESEARCH & DEVELOPMENT CO., LTD. (CN) | 2014-10-15 | — | — | CN | disclosed |
| CN-102749401-B | Inspection method of traditional Chinese medicine composition twenty-five-ingredient lung disease preparation | SHANDONG ARURA PHARMACEUTICAL RES & DEV CO LTD | 2013-12-18 | — | — | CN | disclosed |
| CN-102759598-A | Quality detection method for 29-componnet stagnation dissipation powder as Tibetan medicinal composition and preparations thereof | SHANDONG ARURA PHARMACEUTICAL RES & DEV CO LTD | 2012-10-31 | — | — | CN | disclosed |
| CN-102749401-A | Quality inspection method of traditional Chinese medicine composition twenty-five-ingredient lung disease preparation | SHANDONG ARURA PHARMACEUTICAL RES & DEV CO LTD | 2012-10-24 | — | — | CN | disclosed |
| EP-0495265-B1 | Acid-labile linker molecules | AKZO NOBEL NV (NL) | 1994-08-03 | — | — | EP | disclosed |
| US-5306809-A | Cancer immune therapy | AKZO N.V. (NL) | 1994-04-26 | — | — | US | disclosed |
| US-5296597-A | Antibiotics | SPA SOCIETA' PRODOTTI ANTIBIOTICI S.P.A. (IT) | 1994-03-22 | — | — | US | disclosed |
| EP-0495265-A1 | Acid-labile linker molecules | Akzo Nobel N.V. (NL) | 1992-07-22 | — | — | EP | disclosed |