Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326409 | 0.85 | SIGMAR1 (0.39) | TRPM8MAOBTAAR1CYP2C19MAPT | |
| SCHEMBL9324295 | 0.84 | KCNH2 (0.49) | TRPM8MAPTKCNH2POLBALDH1A1 | |
| SCHEMBL9326474 | 0.83 | LMNA (0.44) | TRPM8CYP2C19MAPTCYP1A2CYP2D6 | |
| SCHEMBL9326153 | 0.81 | DRD2 (0.37) | MAOBTAAR1MAPTDRD2DRD3 | |
| SCHEMBL9325748 | 0.70 | KCNH2 (0.49) | TRPM8MAPTKCNH2LMNAPOLB | |
| SCHEMBL9324433 | 0.68 | SIGMAR1 (0.39) | MAOBTAAR1MAPTCYP2D6TSHR | |
| SCHEMBL10529828 | 0.67 | HTR2A (0.45) | MAPTKCNH2LMNAGAAALDH1A1 | |
| SCHEMBL9279890 | 0.67 | TAAR1 (0.46) | TRPM8TAAR1TSHRDRD2DRD3 | |
| SCHEMBL23713771 | 0.65 | MAOB (0.43) | MAOBMAPTGAASIGMAR1ALDH1A1 | |
| SCHEMBL5632446 | 0.64 | KCNH2 (0.56) | MAOBMAPTDRD3KCNH2GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310941-A | Antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-10 | — | — | US | disclosed |
| US-5208252-A | Antiarrhythmia | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |