SCHEMBL935645

SCHEMBL935645

O=C(O)Nc1ccc(C(F)(F)F)cc1

nearest known ligand 0.73

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 2/20 0.73
RAB9A P51151 2/20 0.67
NPC1 O15118 1/20 0.67
KIF11 P52732 1/20 0.61
TGM2 P21980 1/20 0.61
TRPV1 Q8NER1 2/20 0.58
PTGS1 P23219 2/20 0.58
L3MBTL1 Q9Y468 1/20 0.57
RORC P51449 1/20 0.56
MEN1 O00255 1/20 0.56
MAPT P10636 1/20 0.56
HTT P42858 1/20 0.56
KMT2A Q03164 1/20 0.56
ALDH1A1 P00352 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15603135 0.89 EPHX2 (0.59) EPHX2RAB9ANPC1KIF11TGM2
SCHEMBL3462701 0.89 MAOB (0.61) EPHX2RAB9ANPC1KIF11TGM2
SCHEMBL3462699 0.89 MAOB (0.61) EPHX2RAB9ANPC1KIF11TGM2
SCHEMBL15603136 0.89 EPHX2 (0.59) EPHX2RAB9ANPC1KIF11TGM2
SCHEMBL2518624 0.84 EPHX2 (0.76) EPHX2RAB9ANPC1KIF11TGM2
SCHEMBL28729179 0.84 EPHX2 (1.00) EPHX2RAB9ANPC1KIF11TGM2
SCHEMBL11003408 0.84 EPHX2 (1.00) EPHX2RAB9ANPC1KIF11TGM2
SCHEMBL11428736 0.83 EPHX2 (0.68) EPHX2RAB9ANPC1KIF11TGM2
SCHEMBL28459398 0.83 EPHX2 (0.52) EPHX2RAB9ANPC1KIF11TGM2
SCHEMBL2096237 0.83 EPHX2 (0.52) EPHX2RAB9ANPC1KIF11TGM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105705484-B Carbanilate derivative as formyl peptide receptor conditioning agent 阿勒根公司 2018-09-14 CN claimed
CN-105705484-A Phenylcarbamate derivatives as formyl peptide receptor modulators 阿勒根公司 2016-06-22 CN claimed
EP-1765325-A4 2-SUBSTITUTED HETEROARYL COMPOUNDS SYNTA PHARMACEUTICALS CORP (US) 2009-08-12 EP claimed
EP-1694658-B1 METHOD FOR THE PRODUCTION OF A THIAZOLO [3,4,5-DE] [4,1]BENZOTHIAZEPINE-TYPE PRODUCT AVENTIS PHARMA SA (FR) 2009-02-25 EP claimed
EP-1765325-A2 2-SUBSTITUTED HETEROARYL COMPOUNDS Synta Pharmaceuticals Corporation (US) 2007-03-28 EP claimed
EP-1694658-A1 METHOD FOR THE PRODUCTION OF A THIAZOLO [3,4,5-DE] [4,1]BENZOTHIAZEPINE-TYPE PRODUCT Aventis Pharma S.A. (FR) 2006-08-30 EP claimed
WO-2006007532-A2 2-SUBSTITUTED HETEROARYL COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2006-01-19 WO claimed
WO-2005066146-A1 METHOD FOR THE PRODUCTION OF A THIAZOLO[3,4,5-DE][4,1]BENZOTHIAZEPINE-TYPE PRODUCT AVENTIS PHARMA S.A. (FR) 2005-07-21 WO claimed
EP-0866793-B1 NITROIMIDAZOLE ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF CHIRON CORP (US) 2004-10-27 EP claimed
EP-0923562-B1 SUBSTITUTED P-TRIFLUOROMETHYLPHENYLURACILS BAYER AG (DE) 2002-10-09 EP claimed
US-6130225-A Substituted p-trifluoromethylphenyluracils BAYER AKTIENGESELLSCHAFT (DE) 2000-10-10 US claimed
EP-0923562-A1 SUBSTITUTED P-TRIFLUOROMETHYLPHENYLURACILS BAYER AG (DE) 1999-06-23 EP claimed
WO-1998006706-A1 SUBSTITUTED P-TRIFLUOROMETHYLPHENYLURACILS BAYER AKTIENGESELLSCHAFT (DE) 1998-02-19 WO claimed
JP-2598819-B2 1997-04-09 JP claimed
EP-0340243-B1 CC-1065 ANALOGS UPJOHN CO (US) 1994-09-28 EP claimed
EP-0509795-A2 Carbamates of rapamycin AMERICAN HOME PRODUCTS CORPORATION (US) 1992-10-21 EP claimed
US-5118678-A Antibody inhibitors, antiinflammatory agents, fungicides, antitumor agents AMERICAN HOME PRODUCTS CORPORATION (US) 1992-06-02 US claimed
EP-0340243-A1 CC-1065 ANALOGS. UPJOHN CO (US) 1989-11-08 EP claimed
WO-1988004659-A2 NOVEL CC-1065 ANALOGS THE UPJOHN COMPANY (US) 1988-06-30 WO claimed
US-20230227409-A1 QUINOLINONE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS IDEAYA BIOSCIENCES, INC. 2023-07-20 US disclosed
WO-2023101256-A1 5-ALPHA-REDUCTASE INHIBITOR, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND USE THEREOF 주식회사 팜어스바이오사이언스 2023-06-08 WO disclosed
WO-2023057371-A1 1,2,4-OXADIAZOL-5-ONE DERIVATIVES FOR THE TREATMENT OF CANCER BASILEA PHARMACEUTICA INTERNATIONAL AG, ALLSCHWIL (CH) 2023-04-13 WO disclosed
US-20230067159-A1 ROR-GAMMA-T INHIBITOR, PREPARATION METHOD THEREOF AND USE THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2023-03-02 US disclosed
WO-2022250069-A1 SULFUR-CONTAINING PYRAZOLE COMPOUND AND NOXIOUS ORGANISM CONTROL AGENT INCLUDING SULFUR-CONTAINING PYRAZOLE COMPOUND AS ACTIVE INGREDIENT 三井化学アグロ株式会社 2022-12-01 WO disclosed
EP-4003983-A1 1,2,4-OXADIAZOL-5-ONE DERIVATIVES FOR THE TREATMENT OF CANCER Basilea Pharmaceutica International AG (CH) 2022-06-01 EP disclosed
CN-114174291-A 1,2, 4-oxadiazol-5-one derivatives for the treatment of cancer 巴斯利尔药物国际股份公司 2022-03-11 CN disclosed
WO-2021252681-A1 QUINOLINONE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS IDEAYA BIOSCIENCES, INC. (US) 2021-12-16 WO disclosed
US-11008301-B2 Piperidinone formyl peptide 2 receptor agonists BRISTOL-MYERS SQUIBB COMPANY (US) 2021-05-18 US disclosed
EP-3634955-B1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-03-31 EP disclosed
US-20200207735-A1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2020-07-02 US disclosed
EP-3634955-A1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AGONISTS Bristol-Myers Squibb Company (US) 2020-04-15 EP disclosed
CN-107501368-B Synthesis of doramectin derivative and insecticidal application thereof 中国科学院成都生物研究所 2020-02-21 CN disclosed
US-10556889-B1 Salvinorin derivatives Blue Sky Pharmaceuticals, LLC (US) 2020-02-11 US disclosed
WO-2018227058-A1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-12-13 WO disclosed
CN-105705484-B Carbanilate derivative as formyl peptide receptor conditioning agent 阿勒根公司 2018-09-14 CN disclosed
US-9926264-B2 Phenylcarbamate derivatives as formyl peptide receptor modulators ALLERGAN, INC. (US) 2018-03-27 US disclosed
US-20160272581-A1 PHENYLCARBAMATE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS ALLERGAN, INC. (US) 2016-09-22 US disclosed
CN-105705484-A Phenylcarbamate derivatives as formyl peptide receptor modulators 阿勒根公司 2016-06-22 CN disclosed
CN-101130526-B Aryl carbonyl derivatives as therapeutic agents NOVO NORDISK AS 2013-07-10 CN disclosed
WO-2011010015-A1 PIPERIDINE COMPOUNDS, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME LES LABORATOIRES SERVIER (FR) 2011-01-27 WO disclosed
EP-2277863-A1 Piperidine derivatives, process for their preparation and pharmaceutical compositions containing them Les Laboratoires Servier (FR) 2011-01-26 EP disclosed
WO-2010103381-A1 SPIROCYCLIC PIPERIDINE DERIVATIVES AS TRPM 8 MODULATORS GLENMARK PHARMACEUTICALS S.A. (CH) 2010-09-16 WO disclosed
US-20090181942-A1 TRICYCLIC COMPOUNDS DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-07-16 US disclosed
EP-1694658-B1 METHOD FOR THE PRODUCTION OF A THIAZOLO [3,4,5-DE] [4,1]BENZOTHIAZEPINE-TYPE PRODUCT AVENTIS PHARMA SA (FR) 2009-02-25 EP disclosed
WO-2009009411-A1 SUBSTITUTED HETEROCYCLIC ETHERS AND THEIR USE IN CNS DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 2009-01-15 WO disclosed
EP-1939205-A1 TRICYCLIC COMPOUND Daiichi Sankyo Company, Limited (JP) 2008-07-02 EP disclosed
CN-101130526-A Aryl carbonyl derivatives as therapeutic agents NOVO NORDISK AS (DK) 2008-02-27 CN disclosed
EP-1620391-A4 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2007-10-31 EP disclosed
EP-1694658-A1 METHOD FOR THE PRODUCTION OF A THIAZOLO [3,4,5-DE] [4,1]BENZOTHIAZEPINE-TYPE PRODUCT Aventis Pharma S.A. (FR) 2006-08-30 EP disclosed
EP-1659121-A1 1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVE TAISHO PHARMACEUTICAL CO., LTD (JP) 2006-05-24 EP disclosed
WO-2006043121-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS RANBAXY LABORATORIES LIMITED (IN) 2006-04-27 WO disclosed
EP-1620391-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Bristol-Myers Squibb Company (US) 2006-02-01 EP disclosed
CN-1678311-A Arylcarbonyl derivatives useful as therapeutic agents NOVO NORDISK AS (DK) 2005-10-05 CN disclosed
WO-2005066146-A1 METHOD FOR THE PRODUCTION OF A THIAZOLO[3,4,5-DE][4,1]BENZOTHIAZEPINE-TYPE PRODUCT AVENTIS PHARMA S.A. (FR) 2005-07-21 WO disclosed
WO-2004098516-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2004-11-18 WO disclosed
US-6713468-B2 AS ANTICONVULSANTS; FOR THERAPY AND PROPHYLAXIS OF ISCHAEMIAS, ANOXIA, NEURODEGENERATIVE DISEASES AVENTIS PHARMA S.A. (FR) 2004-03-30 US disclosed
US-20030055031-A1 Methods of using thiazolobenzoheterocycles RHONE-POULENC RORER S.A. 2003-03-20 US disclosed
EP-1000067-B1 THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME AVENTIS PHARMA SA (FR) 2002-10-23 EP disclosed
US-6448241-B1 THESE COMPOUNDS ARE ANTICONVULSANTS AND INTERFERE WITH GLUTAMATERGIC TRANSMISSION AND ARE THEREFORE USEFUL FOR THE TREATMENT OR PREVENTION OF ALL ISCHAEMIAS FOLLOWING CEREBROVASCULAR ACCIDENTS AVENTIS PHARMA S.A. (FR) 2002-09-10 US disclosed
US-6444616-B1 HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 2002-09-03 US disclosed
EP-0966473-B1 THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME AVENTIS PHARMA SA (FR) 2002-07-24 EP disclosed
US-6423715-B1 ANTICONVULSANTS AVENTIS PHARMA S.A. (FR) 2002-07-23 US disclosed
US-6288075-B1 ANTIEPILEPTIC AGENTS; NERVOUS SYSTEM, BRAIN, AND CARDIOVASCULAR DISORDERS RHONE-POULENC RORER S.A. (FR) 2001-09-11 US disclosed
US-6130225-A Substituted p-trifluoromethylphenyluracils BAYER AKTIENGESELLSCHAFT (DE) 2000-10-10 US disclosed
EP-1025086-A1 BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS MERCK PATENT GmbH (DE) 2000-08-09 EP disclosed
EP-1000067-A1 THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME Aventis Pharma S.A. (FR) 2000-05-17 EP disclosed
EP-0966473-A1 THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME Aventis Pharma S.A. (FR) 1999-12-29 EP disclosed
WO-1999016751-A1 BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS MERCK PATENT GMBH (DE) 1999-04-08 WO disclosed
WO-1999005147-A1 THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME RHONE-POULENC RORER S.A. (FR) 1999-02-04 WO disclosed
US-5866596-A DRUGS WITH ANTIINFLAMMATORY AND ANALGESIC PROPERTIES. LABORATORIES UPSA (FR) 1999-02-02 US disclosed
WO-1998038194-A1 THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME RHONE-POULENC RORER S.A. (FR) 1998-09-03 WO disclosed
EP-0340243-B1 CC-1065 ANALOGS UPJOHN CO (US) 1994-09-28 EP disclosed
US-5332837-A Antitumor THE UPJOHN COMPANY (US) 1994-07-26 US disclosed
EP-0509795-A2 Carbamates of rapamycin AMERICAN HOME PRODUCTS CORPORATION (US) 1992-10-21 EP disclosed
US-5118678-A Antibody inhibitors, antiinflammatory agents, fungicides, antitumor agents AMERICAN HOME PRODUCTS CORPORATION (US) 1992-06-02 US disclosed
EP-0340243-A1 CC-1065 ANALOGS. UPJOHN CO (US) 1989-11-08 EP disclosed
WO-1988004659-A2 NOVEL CC-1065 ANALOGS THE UPJOHN COMPANY (US) 1988-06-30 WO disclosed
WO-1988004659-A2 NOVEL CC-1065 ANALOGS THE UPJOHN COMPANY (US) 1988-06-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230067159-A1 ROR-GAMMA-T INHIBITOR, PREPARATION METHOD THEREOF AND USE THEREOF RORC, RORB, RORA EPHX2 1247/4885RAB9A 1245/4885NPC1 1992/4885
US-20030055031-A1 Methods of using thiazolobenzoheterocycles SLCO2B1, SLCO1B1, CYP21A2 EPHX2 216/4885RAB9A 2835/4885NPC1 1069/4885
US-20230227409-A1 QUINOLINONE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS MAT2B, MAT2A, MAT1A EPHX2 2260/4885RAB9A 953/4885NPC1 2783/4885
US-20200207735-A1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AGONISTS FPR1, FPR2, FPR3 EPHX2 2262/4885RAB9A 3396/4885NPC1 1469/4885
US-10556889-B1 Salvinorin derivatives OPRD1, OPRK1, OPRL1 EPHX2 3131/4885RAB9A 1009/4885NPC1 1602/4885
US-20160272581-A1 PHENYLCARBAMATE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS FPR2, FPR1, FPR3 EPHX2 2940/4885RAB9A 4721/4885NPC1 1890/4885
US-20090181942-A1 TRICYCLIC COMPOUNDS FDFT1, COASY, HMGCR EPHX2 801/4885RAB9A 4041/4885NPC1 187/4885
US-11008301-B2 Piperidinone formyl peptide 2 receptor agonists FPR1, FPR2, FPR3 EPHX2 2262/4885RAB9A 3396/4885NPC1 1469/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.