Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL926219 | 0.97 | — | — | |
| Potassium Ion SCHEMBL3131828 | 0.97 | — | — | |
| Potassium Ion SCHEMBL3897706 | 0.95 | — | — | |
| Ammonia Solution, Strong SCHEMBL976623 | 0.95 | — | — | |
| Potassium Ion SCHEMBL5803916 | 0.87 | SLC34A1 (0.32) | — | |
| SCHEMBL9098975 | 0.82 | — | — | |
| Tetrabuthylammonium SCHEMBL2824667 | 0.79 | SLC22A1 (0.41) | — | |
| Potassium Ion SCHEMBL5689772 | 0.77 | — | — | |
| SCHEMBL6645670 | 0.77 | TSHR (0.38) | — | |
| SCHEMBL6998232 | 0.74 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218007-B1 | OPTICALLY ACTIVE ISOMERS OF KETOTIFEN AND THERAPEUTICALLY ACTIVE METABOLITES THEREOF | BRIDGE PHARMA INC (US) | 2011-07-20 | — | — | EP | disclosed |
| US-7872025-B2 | Optically active isomers of ketotifen and therapeutically active metabolites thereof | BRIDGE PHARMA, INC. (US) | 2011-01-18 | — | — | US | disclosed |
| US-7557128-B2 | Optically active isomers of ketotifen and therapeutically active metabolites thereof | BRIDGE PHARMA, INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-20090149502-A1 | Optically active isomers of ketotifen and therapeutically active metabolites thereof | ABERG A K GUNNAR | 2009-06-11 | — | — | US | disclosed |
| US-20080287498-A1 | Having antiallergic and anti-inflammatory effects while being devoid of the severe dose-limiting sedative side effects of ketotifen | ABERG A K GUNNAR | 2008-11-20 | — | — | US | disclosed |
| US-7226934-B1 | Optically active isomers of ketotifen and therapeutically active metabolites thereof | BRIDGE PHARMA, INC. (US) | 2007-06-05 | — | — | US | disclosed |
| EP-1218007-A4 | OPTICALLY ACTIVE ISOMERS OF KETOTIFEN AND THERAPEUTICALLY ACTIVE METABOLITES THEREOF | BRIDGE PHARMA INC (US) | 2003-04-09 | — | — | EP | disclosed |
| CN-1391475-A | Optical isomers of ketotifen and therapeutically active metabolites thereof | BRIDGE PHARMA INC (US) | 2003-01-15 | — | — | CN | disclosed |
| EP-1218007-A1 | OPTICALLY ACTIVE ISOMERS OF KETOTIFEN AND THERAPEUTICALLY ACTIVE METABOLITES THEREOF | Bridge Pharma, Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001019367-A1 | OPTICALLY ACTIVE ISOMERS OF KETOTIFEN AND THERAPEUTICALLY ACTIVE METABOLITES THEREOF | BRIDGE PHARMA, INC. (US) | 2001-03-22 | — | — | WO | disclosed |