Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of 4-Chloro-Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 12/20 | 0.95 |
| ▸ | CA1 | P00915 | 11/20 | 0.95 |
| ▸ | CES2 | O00748 | 2/20 | 0.59 |
| ▸ | CES1 | P23141 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Chloro-Benzoic Acid SCHEMBL9316882 | 0.95 | CA2 (0.95) | CA2CA1CES2CES1ALOX15 | |
| 4-Chloro-Benzoic Acid SCHEMBL11173039 | 0.95 | CA2 (0.95) | CA2CA1CES2CES1ALOX15 | |
| 4-Chloro-Benzoic Acid SCHEMBL11710684 | 0.95 | CA2 (0.95) | CA2CA1CES2CES1ALOX15 | |
| 4-Chloro-Benzoic Acid SCHEMBL9316878 | 0.95 | CA2 (0.95) | CA2CA1CES2CES1ALOX15 | |
| 4-Chloro-Benzoic Acid SCHEMBL9149742 | 0.95 | CA2 (0.95) | CA2CA1CES2CES1ALOX15 | |
| 4-Chloro-Benzoic Acid SCHEMBL8024002 | 0.95 | CA2 (1.00) | CA2CA1CES2CES1ALOX15 | |
| 4-Chloro-Benzoic Acid SCHEMBL2918289 | 0.95 | CA2 (0.95) | CA2CA1CES2CES1ALOX15 | |
| 4-Chloro-Benzoic Acid SCHEMBL10603885 | 0.95 | CA2 (0.95) | CA2CA1CES2CES1ALOX15 | |
| 4-Chloro-Benzoic Acid SCHEMBL2918296 | 0.95 | CA2 (0.95) | CA2CA1CES2CES1ALOX15 | |
| 4-Chloro-Benzoic Acid SCHEMBL379138 | 0.95 | CA2 (0.95) | CA2CA1CES2CES1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250243137-A1 | METHOD FOR PREPARING 3-CHLOROBICYCLO[3.2.1]-3-OCTEN-2-OL | SHANDONG WEIFANG RAINBOW CHEMICAL CO.,LTD (CN) | 2025-07-31 | — | — | US | claimed |
| WO-2024152641-A1 | PREPARATION METHOD FOR 3-CHLOROBICYCLO[3.2.1]-3-OCTEN-2-OL | 山东潍坊润丰化工股份有限公司 | 2024-07-25 | — | — | WO | claimed |
| CN-112679384-B | Preparation method of p-cyanobenzoic acid | 国药集团化学试剂有限公司 | 2023-04-07 | — | — | CN | claimed |
| CN-112679384-A | Preparation method of p-cyanobenzoic acid | 国药集团化学试剂有限公司 | 2021-04-20 | — | — | CN | claimed |
| CN-111574322-A | Preparation method of difluoromethyl aromatic compound | 南京工业大学 | 2020-08-25 | — | — | CN | claimed |
| JP-57124349-A | — | — | None | — | — | JP | disclosed |
| US-20250243137-A1 | METHOD FOR PREPARING 3-CHLOROBICYCLO[3.2.1]-3-OCTEN-2-OL | SHANDONG WEIFANG RAINBOW CHEMICAL CO.,LTD (CN) | 2025-07-31 | — | — | US | disclosed |
| CN-116514635-B | Process for preparing 3-chlorobicyclo [3.2.1] -3-octen-2-ol | 山东潍坊润丰化工股份有限公司 | 2025-02-14 | — | — | CN | disclosed |
| CN-115974697-B | Method for catalytic synthesis of 4' -chloro-2-nitrobiphenyl | 南京工业大学 | 2024-11-05 | — | — | CN | disclosed |
| WO-2024152641-A1 | PREPARATION METHOD FOR 3-CHLOROBICYCLO[3.2.1]-3-OCTEN-2-OL | 山东潍坊润丰化工股份有限公司 | 2024-07-25 | — | — | WO | disclosed |
| CN-116514635-A | Process for preparing 3-chlorobicyclo [3.2.1] -3-octen-2-ol | 山东潍坊润丰化工股份有限公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-115784837-B | Process for preparing 3-chlorobicyclo [3.2.1] -3-octen-2-ol | 山东潍坊润丰化工股份有限公司 | 2023-04-25 | — | — | CN | disclosed |
| US-20160046577-A1 | N-Haloalkylindoline Intermediates, Their Process And Use In Preparation of Silodosin And its Derivatives | MANKIND PHARMA LTD (IN) | 2016-02-18 | — | — | US | disclosed |
| EP-2984070-A1 | N-HALOALKYLINDOLINE INTERMEDIATES, THEIR PROCESS AND USE IN PREPARATION OF SILODOSIN AND ITS DERIVATIVES | Mankind Research Centre (IN) | 2016-02-17 | — | — | EP | disclosed |
| WO-2014167507-A1 | N-HALOALKYLINDOLINE INTERMEDIATES, THEIR PROCESS AND USE IN PREPARATION OF SILODOSIN AND ITS DERIVATIVES | MANKIND RESEARCH CENTRE (IN) | 2014-10-16 | — | — | WO | disclosed |
| CN-101407510-A | Preparation of duloxetine hydrochloride intermediate | ZHEJIANG HUAHAI PHARM CO LTD (CN) | 2009-04-15 | — | — | CN | disclosed |
| US-5185471-A | Reacting 5-halo-2-nitrobenzotrifluorides with inorganic base to form 1,1*-oxy-Bis(3-trifluoromethyl-4-nitrobenzen using benzoate catalyst | OCCIDENTAL CHEMICAL CORPORATION (US) | 1993-02-09 | — | — | US | disclosed |
| EP-0509241-A2 | A novel method for ether formation | OCCIDENTAL CHEMICAL CORPORATION (US) | 1992-10-21 | — | — | EP | disclosed |
| US-4723016-A | Preparation of anhydrous organic acid salts | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-02-02 | — | — | US | disclosed |
| JP-S57124349-A | IMAGE FORMATION METHOD | KIMOTO & CO LTD | 1982-08-03 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250243137-A1 | METHOD FOR PREPARING 3-CHLOROBICYCLO[3.2.1]-3-OCTEN-2-OL | OSTC, HAO2, ODC1 | CA2 71/4885CA1 728/4885CES2 302/4885 |
| US-20160046577-A1 | N-Haloalkylindoline Intermediates, Their Process And Use In Preparation of Silodosin And its Derivatives | ADRA1D, ADRA1A, ADRB1 | CA2 2966/4885CA1 4507/4885CES2 1397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.