Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 5/20 | 0.40 |
| ▸ | BCHE | P06276 | 7/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504640 | 0.92 | PTGER4 (0.37) | AGTR2TRPM8 | |
| SCHEMBL9503511 | 0.84 | TAS1R3 (0.41) | — | |
| SCHEMBL9504551 | 0.75 | NPSR1 (0.42) | BCHE | |
| SCHEMBL9503474 | 0.74 | NPC1 (0.40) | AGTR2CA1CA2ACHEAGTR1 | |
| SCHEMBL9507079 | 0.73 | ADRA2A (0.39) | — | |
| SCHEMBL9503470 | 0.72 | CA1 (0.40) | AGTR2CA1CA2ACHESCN9A | |
| SCHEMBL21091907 | 0.69 | KMT2A (0.51) | — | |
| SCHEMBL21091908 | 0.69 | KMT2A (0.51) | — | |
| SCHEMBL9814112 | 0.68 | MAOA (0.45) | AGTR2BCHECA1CA2ACHE | |
| SCHEMBL9507191 | 0.66 | TAS1R3 (0.36) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321968-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| US-5151414-A | Hypotensive agents | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1992-09-29 | — | — | US | disclosed |
| US-5070106-A | HYPOTENSIVES, CEREBRAL DISORDERS | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1991-12-03 | — | — | US | disclosed |