Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP19 | O94966 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.42 |
| ▸ | HPGD | P15428 | 10/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 12/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.40 |
| ▸ | USP2 | O75604 | 6/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 10/20 | 0.39 |
| ▸ | CASP7 | P55210 | 8/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685229 | 0.88 | USP19 (0.51) | USP19ALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL9685430 | 0.76 | USP19 (0.48) | USP19ALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL10678247 | 0.76 | CASP1 (0.47) | ALDH1A1HPGDCYP1A2HSD17B10CYP3A4 | |
| Hydrochloric Acid SCHEMBL10508297 | 0.75 | CASP1 (0.47) | ALDH1A1HPGDCYP1A2HSD17B10CYP3A4 | |
| SCHEMBL9686606 | 0.72 | ALDH1A1 (0.43) | ALDH1A1HPGDTAAR1CYP1A2HSD17B10 | |
| SCHEMBL9686858 | 0.71 | HTR3A (0.55) | USP19ALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL9684556 | 0.69 | LMNA (0.51) | ALDH1A1HPGDHSD17B10SMN1; SMN2CASP1 | |
| SCHEMBL9686198 | 0.68 | TSHR (0.40) | USP19TSHRKMT2AMEN1 | |
| SCHEMBL10048250 | 0.68 | CASP1 (0.57) | ALDH1A1HPGDCYP1A2HSD17B10CYP3A4 | |
| SCHEMBL9685325 | 0.68 | CYP1A2 (0.46) | USP19ALDH1A1HPGDCYP1A2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |