Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAPDH | P04406 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834514 | 0.80 | HRH1 (0.41) | ALDH1A1MAPT | |
| SCHEMBL9833192 | 0.79 | ALDH1A1 (0.37) | POLBALDH1A1GLSUSP2HDAC1 | |
| SCHEMBL9832722 | 0.78 | MPO (0.39) | L3MBTL1ALDH1A1GLSTAAR1MAPT | |
| SCHEMBL9832047 | 0.77 | HRH1 (0.45) | SMN1; SMN2GLSHDAC1 | |
| SCHEMBL9832110 | 0.76 | TDP1 (0.41) | L3MBTL1GLSTDP1ALOX15 | |
| SCHEMBL9833469 | 0.75 | HDAC1 (0.46) | POLBNPC1GLSTAAR1RAB9A | |
| SCHEMBL9837576 | 0.74 | ALOX5 (0.46) | POLBALOX15 | |
| SCHEMBL9833331 | 0.73 | HDAC1 (0.47) | TAAR1HDAC1HDAC8 | |
| SCHEMBL30884578 | 0.72 | POLB (0.70) | SMN1; SMN2POLBTSHRL3MBTL1ALDH1A1 | |
| SCHEMBL8794155 | 0.71 | SMN1; SMN2 (0.42) | SMN1; SMN2POLBTSHRL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129846-B1 | (3-AMINO-1H-PYRAZOL-4-YL)(ARYL)METHANONES | AMERICAN CYANAMID COMPANY (US) | 1991-05-08 | — | — | EP | claimed |