Arachidonyl Trifluoromethylketone

Arachidonyl Trifluoromethylketone

SCHEMBL9880640

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)C(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 12/20 1.00
PLA2G4A P47712 2/20 1.00
ALDH1A1 P00352 2/20 1.00
MAPT P10636 2/20 1.00
BLM P54132 2/20 1.00
PLA2G4B P0C869 1/20 1.00
MGLL Q99685 1/20 1.00
PLA2G4C Q9UP65 1/20 1.00
CES1 P23141 7/20 0.81
PPARG P37231 2/20 0.64
MEN1 O00255 2/20 0.64
KMT2A Q03164 2/20 0.64
HSD17B10 Q99714 2/20 0.64
KDM4E B2RXH2 1/20 0.64
USP2 O75604 1/20 0.64
LMNA P02545 1/20 0.64
TP53 P04637 1/20 0.64
CYP3A4 P08684 1/20 0.64
HSPD1 P10809 1/20 0.64
CYP19A1 P11511 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arachidonyl Trifluoromethylketone SCHEMBL30426991 1.00 FAAH (1.00) FAAHPLA2G4AALDH1A1MAPTBLM
SCHEMBL459981 0.97 FAAH (0.93) FAAHPLA2G4AALDH1A1MAPTBLM
SCHEMBL459980 0.97 FAAH (0.93) FAAHPLA2G4AALDH1A1MAPTBLM
SCHEMBL3679974 0.95 FAAH (0.90) FAAHPLA2G4AALDH1A1MAPTBLM
SCHEMBL3679976 0.95 FAAH (0.90) FAAHPLA2G4AALDH1A1MAPTBLM
SCHEMBL22195368 0.93 FAAH (0.88) FAAHPLA2G4AALDH1A1MAPTBLM
Arachidonic Acid SCHEMBL28819351 0.92 ALDH1A1 (0.85) FAAHPLA2G4AALDH1A1MAPTBLM
SCHEMBL22195422 0.92 FAAH (0.85) FAAHPLA2G4AALDH1A1MAPTBLM
SCHEMBL22222739 0.91 FAAH (0.84) FAAHPLA2G4AALDH1A1MAPTBLM
SCHEMBL24938529 0.89 FAAH (1.00) FAAHPLA2G4AALDH1A1MAPTBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250352615-A1 COMPOSITIONS AND METHODS FOR THE MODULATION OF PIEZO1 AND TRPV4 UNIV DUKE (US) 2025-11-20 US claimed
CN-118846067-A Medicament for preventing or treating scar pregnancy 北京航空航天大学 2024-10-29 CN claimed
WO-2024073476-A2 COMPOSITIONS AND METHODS FOR TREATING CANCER BY REDUCING THE EXPRESSION AND/OR ACTIVITY OF PLA2G10 YALE UNIVERSITY (US) 2024-04-04 WO claimed
EP-4243805-A1 COMBINATION THERAPIES FOR TREATING CORONAVIRUS INFECTION Gbiotech S.À.R.L. (CH) 2023-09-20 EP claimed
WO-2023091901-A1 COMPOSITIONS AND METHODS FOR THE MODULATION OF PIEZO1 AND TRPV4 DUKE UNIVERSITY (US) 2023-05-25 WO claimed
US-20230060937-A1 SIMULTANEOUS GENE EDITING AND HAPLOID INDUCTION SYNGENTA PARTICIPATIONS AG (CH) 2023-03-02 US claimed
WO-2022029334-A1 COMBINATION THERAPIES FOR TREATING CORONAVIRUS INFECTION GBIOTECH S.À.R.L. (CH) 2022-02-10 WO claimed
US-20260137041-A1 SIMULTANEOUS GENE EDITING AND HAPLOID INDUCTION SYNGENTA CROP PROTECTION AG (CH) 2026-05-21 US disclosed
EP-4735431-A2 MK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME GILEAD SCIENCES, INC. (US) 2026-05-06 EP disclosed
EP-4735446-A1 SALTS AND SOLID FORMS OF A COMPOUND THAT MODULATES IRAK4 GILEAD SCIENCES, INC. (US) 2026-05-06 EP disclosed
US-12593765-B2 Simultaneous gene editing and haploid induction SYNGENTA CROP PROTECTION AG (CH) 2026-04-07 US disclosed
US-12590309-B2 Reprogramming of lipid metabolism to inhibit T cell senescence and enhance tumor immunotherapy SAINT LOUIS UNIVERSITY (US) 2026-03-31 US disclosed
EP-3509604-B1 COMBINATION THERAPIES USING IMMUNO-DASH INHIBITORS AND PGE2 ANTAGONISTS TUFTS COLLEGE (US) 2026-02-18 EP disclosed
US-8796251-B2 Compositions and methods for the treatment of glomerulonephritis AVEXXIN AS (NO) 2014-08-05 US disclosed
EP-2745837-A1 Glomerulonephritis Treatment Avexxin AS (NO) 2014-06-25 EP disclosed
US-20120136066-A1 Glomerulonephritis Treatment AVEXXIN AS (NO) 2012-05-31 US disclosed
US-20120136066-A1 Glomerulonephritis Treatment AVEXXIN AS (NO) 2012-05-31 US disclosed
US-20100311843-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF GLOMERULONEPHRITIS AVEXXIN AS (NO) 2010-12-09 US disclosed
WO-2010139482-A1 GLOMERULONEPHRITIS TREATMENT AVEXXIN AS (NO) 2010-12-09 WO disclosed
EP-0860168-B1 Use of central cannbinoid receptor CB1 agonists BAYER HEALTHCARE AG (DE) 2007-08-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12590309-B2 Reprogramming of lipid metabolism to inhibit T cell senescence and enhance tumor immunotherapy PLA2G4A, PLA2G2A, PLA2G1B FAAH 966/4885PLA2G4A 1/4885ALDH1A1 3735/4885
US-20260137041-A1 SIMULTANEOUS GENE EDITING AND HAPLOID INDUCTION CPSF1, RNGTT, PAPSS1 FAAH 2447/4885PLA2G4A 18/4885ALDH1A1 3855/4885
US-20120136066-A1 Glomerulonephritis Treatment SSB, REN, GRHPR FAAH 2933/4885PLA2G4A 2333/4885ALDH1A1 3185/4885
US-20250352615-A1 COMPOSITIONS AND METHODS FOR THE MODULATION OF PIEZO1 AND TRPV4 PIEZO1, PLA2G4A, TRPV4 FAAH 818/4885PLA2G4A 2/4885ALDH1A1 2756/4885
US-20100311843-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF GLOMERULONEPHRITIS REN, SSB, C5 FAAH 2431/4885PLA2G4A 1973/4885ALDH1A1 3753/4885
US-12593765-B2 Simultaneous gene editing and haploid induction CPSF1, PAPSS1, RNGTT FAAH 2303/4885PLA2G4A 20/4885ALDH1A1 4201/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.