Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.56 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP9 | P55211 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorene SCHEMBL2026496 | 0.78 | MAOA (0.58) | MAOACES1BCHEALDH1A1KDM4E | |
| SCHEMBL8329161 | 0.76 | S100A4 (0.45) | MAOACES1BCHEALDH1A1KDM4E | |
| Fluorene SCHEMBL545861 | 0.76 | MAOA (0.68) | MAOACES1BCHEALDH1A1KDM4E | |
| Fluorene SCHEMBL29478468 | 0.76 | MAOA (0.68) | MAOACES1BCHEALDH1A1KDM4E | |
| Fluorene SCHEMBL31388525 | 0.76 | MAOA (0.68) | MAOACES1BCHEALDH1A1KDM4E | |
| Fluorene SCHEMBL8180 | 0.76 | MAOA (0.68) | MAOACES1BCHEALDH1A1KDM4E | |
| Fluorene SCHEMBL29355380 | 0.76 | MAOA (0.68) | MAOACES1BCHEALDH1A1KDM4E | |
| Fluorene SCHEMBL17313625 | 0.74 | MAOA (0.67) | MAOACES1BCHEALDH1A1KDM4E | |
| Fluorene SCHEMBL8378972 | 0.73 | MAOA (0.65) | MAOACES1BCHEALDH1A1KDM4E | |
| Fluorene SCHEMBL1080516 | 0.73 | MAOA (0.65) | MAOACES1BCHEALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594962-B1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORP (US) | 2014-08-27 | — | — | EP | claimed |
| EP-2369006-B1 | Covalent tethering of functional groups to proteins | PROMEGA CORP (US) | 2014-03-12 | — | — | EP | claimed |
| CN-1200012-C | Organic antireflecting coating and its preparation | HYUNDAI ELECTRONICS IND (KR) | 2005-05-04 | — | — | CN | claimed |
| US-11028424-B2 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION (US) | 2021-06-08 | — | — | US | disclosed |
| US-10604745-B2 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule | PROMEGA CORPORATION (US) | 2020-03-31 | — | — | US | disclosed |
| US-20190218592-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORPORATION | 2019-07-18 | — | — | US | disclosed |
| US-10246690-B2 | Mutant hydrolase proteins with enhanced kinetics and functional expression | PROMEGA CORPORATION (US) | 2019-04-02 | — | — | US | disclosed |
| US-10240184-B2 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION (US) | 2019-03-26 | — | — | US | disclosed |
| US-20190085305-A1 | METHOD OF IMMOBILIZING A PROTEIN OR MOLECULE VIA A MUTANT DEHALOGENASE THAT IS BOUND TO AN IMMOBILIZED DEHALOGENASE SUBSTRATE AND LINKED DIRECTLY OR INDIRECTLY TO THE PROTEIN OR MOLECULE | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2019-03-21 | — | — | US | disclosed |
| EP-3179252-B1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | PROMEGA CORP (US) | 2018-11-14 | — | — | EP | disclosed |
| US-10101332-B2 | Covalent tethering of functional groups to proteins and substrates therefor | PROMEGA CORPORATION (US) | 2018-10-16 | — | — | US | disclosed |
| US-20070087400-A1 | Covalent tethering of functional groups to proteins and substrates therefor | PROMEGA CORPORATION | 2007-04-19 | — | — | US | disclosed |
| WO-2006093529-A2 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | PROMEGA CORPORATION (US) | 2006-09-08 | — | — | WO | disclosed |
| CN-1764721-A | Covalent tethering of functional groups to proteins | PROMEGA CORP (US) | 2006-04-26 | — | — | CN | disclosed |
| US-20060024808-A1 | Covalent tethering of functional groups to proteins and substrates therefor | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2006-02-02 | — | — | US | disclosed |
| US-20050272114-A1 | Substrates for covalent tethering to proteins | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2005-12-08 | — | — | US | disclosed |
| EP-1594962-A2 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORPORATION (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20040214258-A1 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION | 2004-10-28 | — | — | US | disclosed |
| WO-2004072232-A9 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORP (US) | 2004-10-14 | — | — | WO | disclosed |
| WO-2004072232-A2 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORPORATION (US) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070087400-A1 | Covalent tethering of functional groups to proteins and substrates therefor | WASF2, NOTUM, YIPF5 | MAOA 3034/4885CES1 518/4885BCHE 589/4885 |
| US-20050272114-A1 | Substrates for covalent tethering to proteins | DDHD2, ABHD14B, AHCYL1 | MAOA 3044/4885CES1 456/4885BCHE 357/4885 |
| US-20190085305-A1 | METHOD OF IMMOBILIZING A PROTEIN OR MOLECULE VIA A MUTANT DEHALOGENASE THAT IS BOUND TO AN IMMOBILIZED DEHALOGENASE SUBSTRATE AND LINKED DIRECTLY OR INDIRECTLY TO THE PROTEIN OR MOLECULE | HDHD5, DDT, DDAH1 | MAOA 614/4885CES1 258/4885BCHE 33/4885 |
| US-20190218592-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | GGT1, HDHD5, DNPH1 | MAOA 2321/4885CES1 355/4885BCHE 359/4885 |
| US-10604745-B2 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule | HDHD5, DDT, DDAH1 | MAOA 614/4885CES1 258/4885BCHE 33/4885 |
| US-11028424-B2 | Covalent tethering of functional groups to proteins | GGT1, HDHD5, DNPH1 | MAOA 2321/4885CES1 355/4885BCHE 359/4885 |
| US-10101332-B2 | Covalent tethering of functional groups to proteins and substrates therefor | WASF2, NOTUM, YIPF5 | MAOA 3034/4885CES1 518/4885BCHE 589/4885 |
| US-20060024808-A1 | Covalent tethering of functional groups to proteins and substrates therefor | WASF2, NOTUM, YIPF5 | MAOA 3034/4885CES1 518/4885BCHE 589/4885 |
| US-10240184-B2 | Covalent tethering of functional groups to proteins | GGT1, HDHD5, DNPH1 | MAOA 2321/4885CES1 355/4885BCHE 359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.