Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH5 | Q6P6C2 | 17/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL67421 | 0.87 | ALKBH5 (0.66) | ALKBH5KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL9176966 | 0.83 | ALKBH5 (0.61) | ALKBH5KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL9619302 | 0.81 | ALKBH5 (0.58) | ALKBH5KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL10405697 | 0.80 | ALDH1A1 (0.53) | ALKBH5KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL11642426 | 0.80 | MAPT (0.45) | ALKBH5KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL10654204 | 0.80 | ALDH1A1 (0.60) | ALKBH5KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL951472 | 0.79 | ALKBH5 (0.73) | ALKBH5ALDH1A1MAPT | |
| SCHEMBL11122450 | 0.79 | ALKBH5 (0.56) | ALKBH5KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL9505312 | 0.78 | ALKBH5 (1.00) | ALKBH5KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL10787351 | 0.78 | ALKBH5 (0.71) | ALKBH5KDM4EALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421501-A2 | KERATIN DYEING COMPOSITIONS COMPRISING A RADICAL SCAVENGER AND USE THEREOF | The Procter & Gamble Company (US) | 2012-02-29 | — | — | EP | claimed |
| US-7988740-B2 | Keratin dyeing compositions comprising a radical scavenger and use thereof | THE PROCTER & GAMBLE COMPANY (US) | 2011-08-02 | — | — | US | claimed |
| US-20110035885-A1 | Keratin Dyeing Compositions Comprising a Radical Scavenger and Use Thereof | NOXELL CORPORATION | 2011-02-17 | — | — | US | claimed |
| WO-2010123863-A2 | KERATIN DYEING COMPOSITIONS COMPRISING A RADICAL SCAVENGER AND USE THEREOF | THE PROCTER & GAMBLE COMPANY (US) | 2010-10-28 | — | — | WO | claimed |
| EP-2421501-A2 | KERATIN DYEING COMPOSITIONS COMPRISING A RADICAL SCAVENGER AND USE THEREOF | The Procter & Gamble Company (US) | 2012-02-29 | — | — | EP | disclosed |
| US-7988740-B2 | Keratin dyeing compositions comprising a radical scavenger and use thereof | THE PROCTER & GAMBLE COMPANY (US) | 2011-08-02 | — | — | US | disclosed |
| US-20110035885-A1 | Keratin Dyeing Compositions Comprising a Radical Scavenger and Use Thereof | NOXELL CORPORATION | 2011-02-17 | — | — | US | disclosed |
| WO-2010123863-A2 | KERATIN DYEING COMPOSITIONS COMPRISING A RADICAL SCAVENGER AND USE THEREOF | THE PROCTER & GAMBLE COMPANY (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110035885-A1 | Keratin Dyeing Compositions Comprising a Radical Scavenger and Use Thereof | KRT18, LPO, CYB5R3 | ALKBH5 413/4885KDM4E 841/4885ALDH1A1 326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.