Menitrazepam

Menitrazepam

SCHEMBL1005402

CN1C(=O)CN=C(C2=CCCCC2)c2cc([N+](=O)[O-])ccc21

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.65
GABRA1 P14867 9/20 0.62
GABRG2 P18507 9/20 0.62
GABRB3 P28472 9/20 0.62
GABRA5 P31644 9/20 0.62
GABRA3 P34903 9/20 0.62
GABRA2 P47869 8/20 0.61
GABRB2 P47870 5/20 0.61
OPRK1 P41145 2/20 0.61
CCKBR P32239 1/20 0.61
MC3R P41968 1/20 0.61
GHSR Q92847 1/20 0.61
CASP6 P55212 2/20 0.45
CASP1 P29466 1/20 0.45
CASP3 P42574 1/20 0.45
CASP4 P49662 1/20 0.45
CASP7 P55210 1/20 0.45
CASP9 P55211 1/20 0.45
GAA P10253 2/20 0.43
TSPO P30536 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13352296 0.83 LMNA (0.47) LMNAGABRA1GABRG2GABRB3GABRA5
Tetrazepam SCHEMBL29500955 0.82 LMNA (0.65) LMNAGABRA1GABRG2GABRB3GABRA5
Tetrazepam SCHEMBL157998 0.82 LMNA (0.65) LMNAGABRA1GABRG2GABRB3GABRA5
Tetrazepam SCHEMBL6832326 0.81 LMNA (0.63) LMNAGABRA1GABRG2GABRB3GABRA5
Clazolam SCHEMBL23014581 0.80 LMNA (0.47) LMNAGABRA1GABRG2GABRB3GABRA5
SCHEMBL5163739 0.79 GABRA1 (0.61) LMNAGABRA1GABRG2GABRB3GABRA5
Nimetazepam SCHEMBL29374297 0.79 LMNA (1.00) LMNAGABRA1GABRG2GABRB3GABRA5
Nimetazepam SCHEMBL79886 0.79 LMNA (1.00) LMNAGABRA1GABRG2GABRB3GABRA5
Nimetazepam SCHEMBL10689471 0.77 LMNA (0.95) LMNAGABRA1GABRG2GABRB3GABRA5
Nimetazepam SCHEMBL9542099 0.77 LMNA (0.95) LMNAGABRA1GABRG2GABRB3GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20260137765-A1 METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STXB) MONOMERS AND OLIGOMERS, AND USES THEREOF INSTITUT CURIE (FR) 2026-05-21 US disclosed
US-12527854-B2 Methods of producing Shiga toxin B-subunit (STxB) monomers and oligomers, and uses thereof INSTITUT CURIE (FR) 2026-01-20 US disclosed
US-12528794-B2 MAO-B inhibitor DRG-MAOB-1 for use in treatment of neurodegenerative diseases BAHCESEHIR UNIVERSITESI (TR) 2026-01-20 US disclosed
US-12478613-B2 Selective MAO-B inhibitor DRG-MAOB-2 for use in treatment of neurodegenerative diseases BAHCESEHIR UNIVERSITESI (TR) 2025-11-25 US disclosed
US-20250281535-A1 ANTI-HUMAN CD45RC BINDING DOMAINS AND USES THEREOF ABOLERIS PHARMA (FR) 2025-09-11 US disclosed
EP-4401842-B1 ANTI-HUMAN CD45RC BINDING DOMAINS AND USES THEREOF ABOLERIS PHARMA (FR) 2025-08-27 EP disclosed
US-20250163130-A1 LIGAND GATED ION CHANNELS AND METHODS OF USE SWITCH BIO, INC. 2025-05-22 US disclosed
US-20040141922-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2004-07-22 US disclosed
US-6680047-B2 FOR USE IN ULTRASOUND IMAGING, CONTRAST AGENTS AMERSHAM HEALTH AS (NO) 2004-01-20 US disclosed
US-20020102215-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-20020102217-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040141922-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 LMNA 1461/4885GABRA1 3124/4885GABRG2 2580/4885
US-12527854-B2 Methods of producing Shiga toxin B-subunit (STxB) monomers and oligomers, and uses thereof STXBP1, RNGTT, UPF1 LMNA 757/4885GABRA1 879/4885GABRG2 1092/4885
US-12528794-B2 MAO-B inhibitor DRG-MAOB-1 for use in treatment of neurodegenerative diseases MAOB, MAOA, ME3 LMNA 1504/4885GABRA1 2361/4885GABRG2 3369/4885
US-20250163130-A1 LIGAND GATED ION CHANNELS AND METHODS OF USE CACNB2, CHRNA2, HCN3 LMNA 1524/4885GABRA1 175/4885GABRG2 148/4885
US-20260137765-A1 METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STXB) MONOMERS AND OLIGOMERS, AND USES THEREOF STXBP1, HBB, UPF1 LMNA 1243/4885GABRA1 1184/4885GABRG2 1329/4885
US-12478613-B2 Selective MAO-B inhibitor DRG-MAOB-2 for use in treatment of neurodegenerative diseases MAOB, MAOA, HTR2B LMNA 2895/4885GABRA1 1458/4885GABRG2 1439/4885
US-20020102215-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 LMNA 1552/4885GABRA1 3027/4885GABRG2 2504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.