SCHEMBL10078862

SCHEMBL10078862

CCC(C)c1ccc(-c2nccc3ccccc23)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.43
RAB9A P51151 4/20 0.43
KDM4E B2RXH2 4/20 0.43
MAPT P10636 3/20 0.43
ALDH1A1 P00352 3/20 0.43
CYP1A2 P05177 2/20 0.43
HPGD P15428 2/20 0.43
CYP2C19 P33261 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
MAPK1 P28482 2/20 0.43
CYP3A4 P08684 1/20 0.43
CASP1 P29466 1/20 0.43
CASP7 P55210 1/20 0.43
ATM Q13315 1/20 0.43
HSD17B10 Q99714 1/20 0.43
L3MBTL1 Q9Y468 3/20 0.43
GPR55 Q9Y2T6 1/20 0.43
KMT2A Q03164 3/20 0.42
GLA P06280 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19752299 1.00 NPC1 (0.43) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL13327607 0.85 KDM4E (0.43) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL10079217 0.84 RAB9A (0.47) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL14270348 0.82 LMNA (0.46) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL12112873 0.80 MAPT (0.58) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL4445451 0.78 KDM4E (0.47) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL20258687 0.78 KDM4E (0.44) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL25443108 0.77 DHODH (0.36) ALDH1A1HPGDHSD17B10DHODH
SCHEMBL25499601 0.77 HTR1A (0.41) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL3142955 0.76 ALDH1A1 (0.65) NPC1RAB9AKDM4EMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3719099-A1 PHOSPHORESCENT MATERIALS Universal Display Corporation (US) 2020-10-07 EP disclosed
US-20200176693-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2020-06-04 US disclosed
EP-3327100-B1 PHOSPHORESCENT MATERIALS UNIVERSAL DISPLAY CORP (US) 2020-05-06 EP disclosed
US-10600975-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2020-03-24 US disclosed
US-20190157576-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2019-05-23 US disclosed
US-10230060-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2019-03-12 US disclosed
EP-3327100-A2 PHOSPHORESCENT MATERIALS Universal Display Corporation (US) 2018-05-30 EP disclosed
US-20180145267-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2018-05-24 US disclosed
US-20180145267-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2018-05-24 US disclosed
US-9911930-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2018-03-06 US disclosed
US-20130248832-A1 Phosphorescent Materials UNIVERSAL DISPLAY CORPORATION 2013-09-26 US disclosed
US-20130248832-A1 Phosphorescent Materials UNIVERSAL DISPLAY CORPORATION 2013-09-26 US disclosed
EP-2121871-B1 PHOSPHORESCENT MATERIALS UNIVERSAL DISPLAY CORP (US) 2013-08-14 EP disclosed
US-8431243-B2 Substituted 2-Phenyl quinoline complex with Iridium; high device efficiency, stability, and processibility UNIVERSAL DISPLAY CORPORATION (US) 2013-04-30 US disclosed
US-8431243-B2 Substituted 2-Phenyl quinoline complex with Iridium; high device efficiency, stability, and processibility UNIVERSAL DISPLAY CORPORATION (US) 2013-04-30 US disclosed
EP-2489716-A2 Phosphorescent materials Universal Display Corporation (US) 2012-08-22 EP disclosed
EP-2465912-A1 Phosphorescent Materials Universal Display Corporation (US) 2012-06-20 EP disclosed
US-20080261076-A1 Substituted 2-Phenyl quinoline complex with Iridium; high device efficiency, stability, and processibility UNIVERSAL DISPLAY CORPORATION (US) 2008-10-23 US disclosed
US-20080261076-A1 Substituted 2-Phenyl quinoline complex with Iridium; high device efficiency, stability, and processibility UNIVERSAL DISPLAY CORPORATION (US) 2008-10-23 US disclosed
WO-2008109824-A2 PHOSPHORESCENT MATERIALS UNIVERSAL DISPLAY CORPORATION (US) 2008-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080261076-A1 Substituted 2-Phenyl quinoline complex with Iridium; high device efficiency, stability, and processibility PCID2, ICMT, ORAI2 NPC1 3616/4885RAB9A 1685/4885KDM4E 2381/4885
US-20200176693-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES RUVBL2, TERT, OR10J3 NPC1 4327/4885RAB9A 1698/4885KDM4E 3403/4885
US-20180145267-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES PIEZO1, ORAI2, ICMT NPC1 3961/4885RAB9A 2283/4885KDM4E 3053/4885
US-10230060-B2 Organic electroluminescent materials and devices RUVBL2, OR10J3, EML4 NPC1 4152/4885RAB9A 2028/4885KDM4E 3060/4885
US-10600975-B2 Organic electroluminescent materials and devices TERT, OR10J3, RUVBL2 NPC1 4327/4885RAB9A 1716/4885KDM4E 3344/4885
US-20190157576-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES PIEZO1, ORAI2, PORCN NPC1 3813/4885RAB9A 2720/4885KDM4E 3726/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.