Glycerol Phenylbutyrate

Glycerol Phenylbutyrate

SCHEMBL10102804

O=C(CCCc1ccccc1)OCC(COC(=O)CCCc1ccccc1)OC(=O)CCCc1ccccc1

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.56
ADRB1 P08588 1/20 0.56
ADRB3 P13945 1/20 0.56
MGLL Q99685 1/20 0.55
LPAR1 Q92633 6/20 0.54
TDP1 Q9NUW8 2/20 0.53
HDAC3 O15379 1/20 0.51
MAPK1 P28482 1/20 0.51
ADRA1A P35348 1/20 0.51
HDAC4 P56524 1/20 0.51
SLC6A3 Q01959 1/20 0.51
HDAC1 Q13547 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
HDAC7 Q8WUI4 1/20 0.51
HDAC2 Q92769 1/20 0.51
HDAC10 Q969S8 1/20 0.51
HDAC11 Q96DB2 1/20 0.51
HDAC8 Q9BY41 1/20 0.51
HDAC6 Q9UBN7 1/20 0.51
HDAC9 Q9UKV0 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3784212 0.93 ALDH1A1 (0.56) ADRB2ADRB1ADRB3MGLLLPAR1
SCHEMBL1892709 0.93 ALDH1A1 (0.56) ADRB2ADRB1ADRB3MGLLLPAR1
SCHEMBL15061844 0.93 MGLL (0.61) ADRB2ADRB1ADRB3MGLLLPAR1
SCHEMBL27665720 0.88 ALDH1A1 (0.69) MGLLLPAR1SMN1; SMN2ALDH1A1LMNA
SCHEMBL31744536 0.88 ADRB2 (0.56) ADRB2ADRB1ADRB3MGLLLPAR1
SCHEMBL4255720 0.86 ALDH1A1 (0.54) MGLLLPAR1MAPK1ALDH1A1LMNA
SCHEMBL15061850 0.86 ADRB2 (0.53) ADRB2ADRB1ADRB3LPAR1TDP1
SCHEMBL15048706 0.86 ADRB2 (0.53) ADRB2ADRB1ADRB3LPAR1TDP1
SCHEMBL15061853 0.86 TLR2 (0.48) ADRB2ADRB1ADRB3MGLLLPAR1
SCHEMBL15048720 0.86 TLR2 (0.48) ADRB2ADRB1ADRB3MGLLLPAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250221954-A1 METHODS TO TREAT, PREVENT, OR REDUCE HYPERAMMONEMIA RUBIN DARREN ALEXANDER (US) 2025-07-10 US claimed
WO-2024261477-A1 COMBINATION OF TLR4 ANTAGONIST, ORNITHINE AND PHENYLACETATE OR PHENYLBUTYRATE YAQRIT LIMITED (GB) 2024-12-26 WO claimed
US-20240282425-A1 AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS LOW GORDON KEITH (US) 2024-08-22 US claimed
WO-2024105168-A1 NOVEL COMBINATIONS USEFUL FOR THE TREATMENTS OF ALS INFLECTIS BIOSCIENCE (FR) 2024-05-23 WO claimed
US-11786494-B2 Methods of modulation of branched chain acids and uses thereof BAYLOR COLLEGE OF MEDICINE (US) 2023-10-17 US claimed
CN-114929209-A Treatment of amyotrophic lateral sclerosis 艾米利克斯制药公司 2022-08-19 CN claimed
CN-114929211-A Compositions of bile acid and phenylbutyric acid compounds 艾米利克斯制药公司 2022-08-19 CN claimed
US-20220249010-A1 METHODS OF ASSESSING HEPATIC ENCEPHALOPATHY MALLINCKRODT PHARMA IP TRADING UNLIMITED COMPANY 2022-08-11 US claimed
EP-3965659-A1 METHODS OF ASSESSING AND TREATING HEPATIC ENCEPHALOPATHY Ocera Therapeutics, Inc. (US) 2022-03-16 EP claimed
CN-113995743-A Therapeutic monitoring of phenylacetic acid prodrugs 伊梅尔迪卡制药公司 2022-02-01 CN claimed
CN-113966194-A Methods of assessing and treating hepatic encephalopathy 欧塞拉治疗有限公司 2022-01-21 CN claimed
WO-2020070760-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF 1,2,3-PROPANETRIYL TRIS(4-PHENYLBUTANOATE) MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) 2020-04-09 WO claimed
WO-2026104570-A1 LIPOSOMAL SUSPENSION AND SYSTEM AND METHOD OF PERITONEAL ADMINISTRATION OF LIPOSOMAL SUSPENSION GENFIT (FR) 2026-05-21 WO disclosed
US-20260076927-A1 PALATABLE COMPOSITIONS INCLUDING SODIUM PHENYLBUTYRATE AND USES THEREOF ACER THERAPEUTICS INC (US) 2026-03-19 US disclosed
US-20260048134-A1 PEPTIDE-BASED DELIVERY AGENT AND METHOD OF MAKING AND USING THE SAME ENDOREL BIOSCIENCES LLC (US) 2026-02-19 US disclosed
US-12551461-B2 Compositions of triglycerides and uses thereof ULTRAGENYX PHARMACEUTICAL INC. (US) 2026-02-17 US disclosed
WO-2010025303-A9 DOSING AND MONITORING PATIENTS ON NITROGEN-SCAVENGING DRUGS HYPERION THERAPEUTICS (US) 2010-06-24 WO disclosed
WO-2010025303-A1 DOSING AND MONITORING PATIENTS ON NITROGEN-SCAVENGING DRUGS HYPERION THERAPEUTICS (US) 2010-03-04 WO disclosed
US-20100008859-A1 METHODS OF TREATMENT USING AMMONIA-SCAVENGING DRUGS HORIZON THERAPEUTICS U.S. HOLDING LLC 2010-01-14 US disclosed
US-20100008859-A1 METHODS OF TREATMENT USING AMMONIA-SCAVENGING DRUGS HORIZON THERAPEUTICS U.S. HOLDING LLC 2010-01-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12551461-B2 Compositions of triglycerides and uses thereof DAGLB, PNLIP, LIPC ADRB2 209/4885ADRB1 142/4885ADRB3 65/4885
US-20260048134-A1 PEPTIDE-BASED DELIVERY AGENT AND METHOD OF MAKING AND USING THE SAME FABP1, LAMP1, SLC7A1 ADRB2 3394/4885ADRB1 3351/4885ADRB3 3818/4885
US-20260076927-A1 PALATABLE COMPOSITIONS INCLUDING SODIUM PHENYLBUTYRATE AND USES THEREOF BCKDK, MLYCD, HADHB ADRB2 3783/4885ADRB1 3436/4885ADRB3 3502/4885
US-20100008859-A1 METHODS OF TREATMENT USING AMMONIA-SCAVENGING DRUGS OAT, SLC1A5, GLS ADRB2 3848/4885ADRB1 3421/4885ADRB3 2980/4885
US-11786494-B2 Methods of modulation of branched chain acids and uses thereof OAT, ABAT, BCKDK ADRB2 2725/4885ADRB1 1772/4885ADRB3 1121/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.