Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 15/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | NQO1 | P15559 | 2/20 | 0.55 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | TDP2 | O95551 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30076102 | 0.90 | IDO1 (0.56) | IDO1KDM4ENQO1MALT1ALDH1A1 | |
| SCHEMBL18791102 | 0.84 | IDO1 (0.56) | IDO1KDM4ENQO1MALT1ALDH1A1 | |
| SCHEMBL416868 | 0.79 | IDO1 (0.46) | IDO1KDM4ENQO1MALT1ALDH1A1 | |
| SCHEMBL14439387 | 0.75 | IDO1 (0.44) | IDO1KDM4ENQO1MALT1ALDH1A1 | |
| SCHEMBL14439350 | 0.74 | IDO1 (0.43) | IDO1KDM4ENQO1MALT1ALDH1A1 | |
| SCHEMBL14439344 | 0.74 | IDO1 (0.43) | IDO1KDM4ENQO1MALT1ALDH1A1 | |
| SCHEMBL20811248 | 0.74 | IDO1 (0.59) | IDO1KDM4ENQO1MALT1ALDH1A1 | |
| Nor-Beta-Lapachone SCHEMBL107599 | 0.73 | MALT1 (0.71) | IDO1KDM4ENQO1MALT1ALDH1A1 | |
| SCHEMBL104948 | 0.73 | IDO1 (0.45) | IDO1KDM4ENQO1MALT1ALDH1A1 | |
| SCHEMBL104950 | 0.73 | IDO1 (0.45) | IDO1KDM4ENQO1MALT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260027161-A1 | BACTERIAL STRAINS FOR TREATING DISEASE | MICROBA IP PTY LTD (AU) | 2026-01-29 | — | — | US | disclosed |
| WO-2023227757-A1 | QUINONE PROTECTED FORMS AND CONJUGATES | CAMBRIDGE ENTERPRISE LIMITED (GB) | 2023-11-30 | — | — | WO | disclosed |
| US-20210161855-A1 | 5-LIPOXYGENASE ANTAGONISTS | Instituto de Medicina Molecular João Lobo Antunes (PT) | 2021-06-03 | — | — | US | disclosed |
| US-10968196-B2 | Substituted β-lapachones for treating cancer | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2021-04-06 | — | — | US | disclosed |
| US-20200095220-A1 | Substituted Beta-Lapachones and Uses Therefor | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2020-03-26 | — | — | US | disclosed |
| US-10450289-B2 | Substituted β-lapachones for treating cancer | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2019-10-22 | — | — | US | disclosed |
| WO-2019050422-A1 | 5-LIPOXYGENASE ANTAGONISTS | INSTITUTO DE MEDICINA MOLECULAR (PT) | 2019-03-14 | — | — | WO | disclosed |
| US-20180170895-A1 | Mitochondria-Targeted Lapachone Compounds and Uses Therefor | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2018-06-21 | — | — | US | disclosed |
| US-20180170895-A1 | Mitochondria-Targeted Lapachone Compounds and Uses Therefor | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2018-06-21 | — | — | US | disclosed |
| WO-2016200934-A1 | MITOCHONDRIA-TARGETED LAPACHONE COMPOUNDS AND USES THEREFOR | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-12-15 | — | — | WO | disclosed |
| EP-2655344-B1 | NOVEL PHENAZINE DERIVATIVES AND THEIR USE | UNIV CATHOLIQUE LOUVAIN (BE) | 2015-11-25 | — | — | EP | disclosed |
| US-9181265-B2 | Substituted 2,3-dihydro-1H-benzo[a]pyrano[2,3-c]phenazines as anti-angiogenic and anti-cancer agents | UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) | 2015-11-10 | — | — | US | disclosed |
| US-9181265-B2 | Substituted 2,3-dihydro-1H-benzo[a]pyrano[2,3-c]phenazines as anti-angiogenic and anti-cancer agents | UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) | 2015-11-10 | — | — | US | disclosed |
| US-20130289030-A1 | NOVEL PHENAZINE DERIVATIVES AND THEIR USES | UNIVERSITE LIBRE DE BRUXELLES (BE) | 2013-10-31 | — | — | US | disclosed |
| US-20130289030-A1 | NOVEL PHENAZINE DERIVATIVES AND THEIR USES | UNIVERSITE LIBRE DE BRUXELLES (BE) | 2013-10-31 | — | — | US | disclosed |
| WO-2012085222-A1 | NOVEL PHENAZINE DERIVATIVES AND THEIR USE | UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) | 2012-06-28 | — | — | WO | disclosed |
| US-7253207-B2 | Quinones as disease therapies | CELLGATE, INC. (US) | 2007-08-07 | — | — | US | disclosed |
| US-7253207-B2 | Quinones as disease therapies | CELLGATE, INC. (US) | 2007-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10968196-B2 | Substituted β-lapachones for treating cancer | NLN, NDUFB7, NDUFB5 | IDO1 3725/4885KDM4E 4216/4885NQO1 21/4885 |
| US-10450289-B2 | Substituted β-lapachones for treating cancer | TFAM, NLN, COX5A | IDO1 4302/4885KDM4E 3656/4885NQO1 59/4885 |
| US-20210161855-A1 | 5-LIPOXYGENASE ANTAGONISTS | ALOX5, ALOX15, ALOX15B | IDO1 342/4885KDM4E 1552/4885NQO1 85/4885 |
| US-20180170895-A1 | Mitochondria-Targeted Lapachone Compounds and Uses Therefor | HADHA, TFAM, NDUFAB1 | IDO1 3778/4885KDM4E 4372/4885NQO1 44/4885 |
| US-20200095220-A1 | Substituted Beta-Lapachones and Uses Therefor | NLN, HADHA, HADHB | IDO1 3971/4885KDM4E 4240/4885NQO1 35/4885 |
| US-20130289030-A1 | NOVEL PHENAZINE DERIVATIVES AND THEIR USES | VEGFA, KDR, FLT4 | IDO1 2619/4885KDM4E 1618/4885NQO1 1052/4885 |
| US-20260027161-A1 | BACTERIAL STRAINS FOR TREATING DISEASE | VIP, SI, ALPI | IDO1 279/4885KDM4E 4679/4885NQO1 4267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.