Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Chicago Sky Blue. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | RECQL | P46063 | 4/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | APEX1 | P27695 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 2/20 | 1.00 |
| ▸ | MIF | P14174 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.90 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.90 |
| ▸ | TST | Q16762 | 2/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chicago Sky Blue SCHEMBL93506 | 1.00 | THRB (1.00) | THRBCYP3A4HPGDMAPK1RECQL | |
| Chicago Sky Blue SCHEMBL29401288 | 1.00 | THRB (1.00) | THRBCYP3A4HPGDMAPK1RECQL | |
| Chicago Sky Blue SCHEMBL29358365 | 1.00 | THRB (1.00) | THRBCYP3A4HPGDMAPK1RECQL | |
| Chicago Sky Blue SCHEMBL14413257 | 0.88 | MEN1 (1.00) | THRBCYP3A4HPGDMAPK1RECQL | |
| Chicago Sky Blue SCHEMBL29415020 | 0.87 | MEN1 (0.98) | THRBCYP3A4HPGDMAPK1RECQL | |
| Evans Blue Free Acid SCHEMBL2437648 | 0.87 | ENPP2 (1.00) | THRBCYP3A4HPGDMAPK1RECQL | |
| Evans Blue Free Acid SCHEMBL29601874 | 0.87 | ENPP2 (1.00) | THRBCYP3A4HPGDMAPK1RECQL | |
| Evans Blue Free Acid SCHEMBL29377040 | 0.87 | ENPP2 (1.00) | THRBCYP3A4HPGDMAPK1RECQL | |
| Evans Blue Free Acid SCHEMBL103701 | 0.87 | ENPP2 (1.00) | THRBCYP3A4HPGDMAPK1RECQL | |
| Evans Blue Free Acid SCHEMBL29381789 | 0.87 | ENPP2 (1.00) | THRBCYP3A4HPGDMAPK1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4393507-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING PERIPHERAL NERVE INJURY | National University Corporation Hokkaido University (JP) | 2024-07-03 | — | — | EP | disclosed |
| WO-2023007779-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING PERIPHERAL NERVE INJURY | 国立大学法人北海道大学 | 2023-02-02 | — | — | WO | disclosed |