SCHEMBL1104873

SCHEMBL1104873

C=C(O)C(O)Cc1cccc(N)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.48
MAOA P21397 3/20 0.48
CYP19A1 P11511 1/20 0.43
ADRB2 P07550 4/20 0.43
CPN1 P15169 1/20 0.39
CPB2 Q96IY4 1/20 0.39
CYP3A4 P08684 1/20 0.38
CASP1 P29466 1/20 0.38
RECQL P46063 1/20 0.38
THRA P10827 1/20 0.37
THRB P10828 1/20 0.37
CA12 O43570 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
CA14 Q9ULX7 1/20 0.36
SIGMAR1 Q99720 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL755879 0.82 KDM6B (0.54) MAOBMAOACYP19A1ADRB2CPN1
SCHEMBL3078044 0.79 MAOB (0.52) MAOBMAOACYP19A1ADRB2CPN1
SCHEMBL9929716 0.78 CYP1A2 (0.46) MAOASIGMAR1
SCHEMBL21368939 0.77 MAOB (0.50) MAOBMAOACYP19A1ADRB2CPN1
SCHEMBL1105056 0.77 MAOB (0.46) MAOBMAOACYP19A1ADRB2CYP3A4
SCHEMBL8281166 0.76 ADRB2 (0.52) MAOBMAOACYP19A1ADRB2CYP3A4
SCHEMBL7865952 0.76 MAOB (0.48) MAOBMAOACYP19A1ADRB2CPN1
SCHEMBL1104874 0.74 PPARG (0.43) MAOBMAOAADRB2CYP3A4
SCHEMBL28286282 0.72 MAOA (0.46) MAOBMAOAADRB2CPN1CPB2
SCHEMBL385392 0.71 SLC7A5 (0.67) RECQLTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11753365-B2 Methods of treating fibrosis NOGRA PHARMA LIMITED (IE) 2023-09-12 US disclosed
US-9913817-B2 Methods for preventing or reducing colon carcinogenesis NOGRA PHARMA LIMITED (IE) 2018-03-13 US disclosed
US-20180064667-A1 METHODS OF TREATING LACTOSE INTOLERANCE NOGRA PHARMA LTD (IE) 2018-03-08 US disclosed
US-9682050-B2 Methods of treating lactose intolerance NOGRA PHARMA LIMITED (IE) 2017-06-20 US disclosed
US-20170056349-A1 Methods for Preventing or Reducing Colon Carcinogenesis NOGRA PHARMA LIMITED (IE) 2017-03-02 US disclosed
US-9561202-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2017-02-07 US disclosed
US-20150265562-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2015-09-24 US disclosed
US-20150265514-A1 METHODS OF INHIBITING HAIR GROWTH NOGRA PHARMA LIMITED (IE) 2015-09-24 US disclosed
US-20150087678-A1 METHODS OF TREATING LACTOSE INTOLERANCE NOGRA PHARMA LIMITED (IE) 2015-03-26 US disclosed
US-8501806-B2 Methods for preventing or reducing colon carcinogenesis NOGRA PHARMA LIMITED (IE) 2013-08-06 US disclosed
US-20130005813-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2013-01-03 US disclosed
US-8153841-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field GIULIANI INTERNATIONAL LIMITED (IE) 2012-04-10 US disclosed
US-20110288177-A1 Methods for Preventing or Reducing Colon Carcinogenesis NOGRA PHARMA LIMITED (IE) 2011-11-24 US disclosed
US-20110288058-A1 Methods for Preventing or Reducing Colon Carcinogenesis NOGRA PHARMA LIMITED (IE) 2011-11-24 US disclosed
US-20110152225-A1 PPAR-Gamma Agonists for the Induction of Cationic Antimicrobial Peptide Expression as Immunoprotective Stimulants NOGRA PHARMA LIMITED (IE) 2011-06-23 US disclosed
US-20090048343-A1 Compounds and Their Salts Specific to the PPAR Receptors and the EGF Receptors and Their Use in the Medical Field NOGRA PHARMA LIMITED (IE) 2009-02-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170056349-A1 Methods for Preventing or Reducing Colon Carcinogenesis NQO1, NFE2L2, CYBB MAOB 250/4885MAOA 359/4885CYP19A1 232/4885
US-20150265562-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field EGFR, ERBB3, FGFR3 MAOB 2770/4885MAOA 3519/4885CYP19A1 770/4885
US-11753365-B2 Methods of treating fibrosis MMP1, MMP8, FABP2 MAOB 950/4885MAOA 1738/4885CYP19A1 4409/4885
US-20110288058-A1 Methods for Preventing or Reducing Colon Carcinogenesis NQO1, NFE2L2, CYBB MAOB 250/4885MAOA 359/4885CYP19A1 232/4885
US-20150087678-A1 METHODS OF TREATING LACTOSE INTOLERANCE LCT, LPL, PPARG MAOB 2825/4885MAOA 3500/4885CYP19A1 2656/4885
US-20110288177-A1 Methods for Preventing or Reducing Colon Carcinogenesis APC, GSTK1, GSTA1 MAOB 1290/4885MAOA 1478/4885CYP19A1 429/4885
US-20090048343-A1 Compounds and Their Salts Specific to the PPAR Receptors and the EGF Receptors and Their Use in the Medical Field EGFR, ERBB3, FGFR3 MAOB 2770/4885MAOA 3519/4885CYP19A1 770/4885
US-20150265514-A1 METHODS OF INHIBITING HAIR GROWTH DCX, HDGF, MKI67 MAOB 276/4885MAOA 247/4885CYP19A1 629/4885
US-20130005813-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field EGFR, ERBB3, FGFR3 MAOB 2770/4885MAOA 3519/4885CYP19A1 770/4885
US-20180064667-A1 METHODS OF TREATING LACTOSE INTOLERANCE LCT, LPL, PPARG MAOB 2825/4885MAOA 3500/4885CYP19A1 2656/4885
US-20110152225-A1 PPAR-Gamma Agonists for the Induction of Cationic Antimicrobial Peptide Expression as Immunoprotective Stimulants PPARG, FABP2, PPARD MAOB 3944/4885MAOA 3577/4885CYP19A1 3120/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.