Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.41 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.39 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.39 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.37 |
| ▸ | DUSP5 | Q16690 | 4/20 | 0.55 |
| ▸ | DUSP6 | Q16828 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.43 |
| ▸ | PKLR | P30613 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306417 | 0.78 | PTGS1 (0.50) | DUSP5DUSP6PTPN1HSD17B10TSHR | |
| SCHEMBL8459698 | 0.78 | HSD17B10 (0.50) | TTRHSD17B10ALDH1A1CYP3A4TSHR | |
| SCHEMBL1347471 | 0.78 | HSD17B10 (0.50) | TTRHSD17B10ALDH1A1CYP3A4TSHR | |
| SCHEMBL1056064 | 0.76 | HSD17B10 (0.48) | TTRHSD17B10ALDH1A1CYP3A4TSHR | |
| SCHEMBL3857115 | 0.76 | ING2 (0.52) | TTRHSD17B10ALDH1A1CYP3A4TSHR | |
| SCHEMBL1128272 | 0.74 | HSD17B10 (0.46) | TTRHSD17B10ALDH1A1CYP3A4TSHR | |
| SCHEMBL126575 | 0.74 | LMNA (0.50) | HSD17B10ALDH1A1CA1CA2LMNA | |
| SCHEMBL9655024 | 0.74 | HSD17B10 (0.46) | TTRHSD17B10ALDH1A1CYP3A4TSHR | |
| SCHEMBL5564627 | 0.74 | CA1 (0.64) | TTRHSD17B10ALDH1A1CYP3A4TSHR | |
| SCHEMBL28022985 | 0.74 | ING2 (0.50) | TTRHSD17B10ALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1611610-A | Method for preparing glycerol oxidase preparation and its use for measuring serum triglyceride | TIANJIN MUNICIPAL MEDICINE SCI (CN) | 2005-05-04 | — | — | CN | claimed |
| CN-1611610-A | Method for preparing glycerol oxidase preparation and its use for measuring serum triglyceride | TIANJIN MUNICIPAL MEDICINE SCI (CN) | 2005-05-04 | — | — | CN | disclosed |
| US-4245110-A | Polyalkylene oxide-containing urethane polyols with sulphonic acid groups | BAYER AKTIENGESELLSCHAFT (DE) | 1981-01-13 | — | — | US | disclosed |