Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 3/20 | 0.76 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.76 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.65 |
| ▸ | OPRD1 known ✓ | P41143 | 1/20 | 0.65 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.57 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.76 |
| ▸ | USP2 | O75604 | 7/20 | 0.76 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.76 |
| ▸ | PGR | P06401 | 6/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.76 |
| ▸ | CNR1 | P21554 | 2/20 | 0.76 |
| ▸ | AR | P10275 | 2/20 | 0.76 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1217308 | 0.99 | CYP3A4 (0.77) | CYP3A4USP2NR3C1PGRADORA3 | |
| SCHEMBL8832311 | 0.96 | CYP3A4 (0.81) | CYP3A4USP2NR3C1PGRADORA3 | |
| SCHEMBL102220 | 0.94 | CYP3A4 (0.83) | CYP3A4USP2NR3C1PGRADORA3 | |
| SCHEMBL5516980 | 0.91 | CYP3A4 (0.81) | CYP3A4USP2NR3C1PGRADORA3 | |
| SCHEMBL7271 | 0.90 | NR3C1 (0.78) | CYP3A4USP2NR3C1PGRADORA3 | |
| SCHEMBL20485505 | 0.90 | NR3C1 (0.78) | CYP3A4USP2NR3C1PGRADORA3 | |
| SCHEMBL11293441 | 0.90 | CYP3A4 (0.72) | CYP3A4USP2NR3C1PGRADORA3 | |
| SCHEMBL13524493 | 0.90 | CYP3A4 (0.83) | CYP3A4USP2NR3C1PGRADORA3 | |
| SCHEMBL4929631 | 0.89 | CYP3A4 (0.77) | CYP3A4USP2NR3C1PGRADORA3 | |
| SCHEMBL4174889 | 0.89 | NR3C1 (0.77) | CYP3A4USP2NR3C1PGRADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291176-A1 | STEROID NEBULISER FORMULATION | Breath Ltd (GB) | 2011-03-09 | — | — | EP | disclosed |
| US-20110045086-A1 | Steroid Nebuliser Formulation | BREATH LTD (GB) | 2011-02-24 | — | — | US | disclosed |
| WO-2009127833-A1 | STEROID NEBULISER FORMULATION | BREATH LTD (GB) | 2009-10-22 | — | — | WO | disclosed |