Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ademetionine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.77 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.77 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.77 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.77 |
| ▸ | PNMT | P11086 | 1/20 | 0.77 |
| ▸ | PCMT1 | P22061 | 1/20 | 0.77 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.77 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.77 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.77 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.77 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.77 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.77 |
| ▸ | AMD1 | P17707 | 8/20 | 0.68 |
| ▸ | FASN | P49327 | 1/20 | 0.51 |
| ▸ | NNMT | P40261 | 2/20 | 0.49 |
| ▸ | MARS1 | P56192 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ademetionine SCHEMBL10400453 | 1.00 | CARM1 (0.77) | CARM1PRMT5PRMT3ADORA3PNMT | |
| Ademetionine SCHEMBL3685223 | 0.97 | CARM1 (0.83) | CARM1PRMT5PRMT3ADORA3PNMT | |
| Ademetionine SCHEMBL1229862 | 0.96 | CARM1 (0.81) | CARM1PRMT5PRMT3ADORA3PNMT | |
| Ademetionine SCHEMBL5465751 | 0.94 | CARM1 (0.88) | CARM1PRMT5PRMT3ADORA3PNMT | |
| Ademetionine SCHEMBL31536258 | 0.90 | AMD1 (0.78) | CARM1PRMT5PRMT3ADORA3PNMT | |
| Ademetionine SCHEMBL1300205 | 0.88 | CARM1 (1.00) | CARM1PRMT5PRMT3ADORA3PNMT | |
| Ademetionine SCHEMBL25176 | 0.88 | CARM1 (1.00) | CARM1PRMT5PRMT3ADORA3PNMT | |
| Ademetionine SCHEMBL29355793 | 0.88 | CARM1 (1.00) | CARM1PRMT5PRMT3ADORA3PNMT | |
| Ademetionine SCHEMBL1300198 | 0.88 | CARM1 (1.00) | CARM1PRMT5PRMT3ADORA3PNMT | |
| Ademetionine SCHEMBL4747876 | 0.87 | CARM1 (0.98) | CARM1PRMT5PRMT3ADORA3PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240316089-A1 | COMBINATIONS FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS | KetaMed MSO, LLC | 2024-09-26 | — | — | US | claimed |
| US-6759395-B2 | ENTERIC COATINGS | ORCHID CHEMICALS & PHARMACEUTICALS, LTD. (IN) | 2004-07-06 | — | — | US | claimed |
| US-20240316089-A1 | COMBINATIONS FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS | KetaMed MSO, LLC | 2024-09-26 | — | — | US | disclosed |
| WO-2024197234-A1 | COMBINATIONS FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS | KetaMed MSO, LLC (US) | 2024-09-26 | — | — | WO | disclosed |
| US-9931356-B2 | Pharmacokinetics of S-adenosylmethionine formulations | METHYLATION SCIENCES INTERNATIONAL SRL (BB) | 2018-04-03 | — | — | US | disclosed |
| EP-3131557-A2 | NOVEL ADEMETIONINE FORMULATIONS | Methylation Sciences International SRL (BB) | 2017-02-22 | — | — | EP | disclosed |
| US-20170027976-A1 | NOVEL ADEMETIONINE FORMULATIONS | METHYLATION SCIENCES INTERNATIONAL SRL (BB) | 2017-02-02 | — | — | US | disclosed |
| US-20160361339-A1 | PHARMACOKINETICS OF S-ADENOSYLMETHIONINE FORMULATIONS | BONAFIDE HEALTH, LLC | 2016-12-15 | — | — | US | disclosed |
| WO-2015159155-A2 | NOVEL ADEMETIONINE FORMULATIONS | METHYLATION SCIENCES INTERNATIONAL SRL (BB) | 2015-10-22 | — | — | WO | disclosed |
| EP-2464358-B1 | IMPROVED PHARMACOKINETICS OF S-ADENOSYLMETHIONINE FORMULATIONS | METHYLATION SCIENCES INTERNAT SRL (BB) | 2015-06-17 | — | — | EP | disclosed |
| US-20140370108-A1 | Pharmacokinetics of S-Adenosylmethionine Formulations | METHYLATION SCIENCES INTERNATIONAL SRL (BB) | 2014-12-18 | — | — | US | disclosed |
| US-20080274997-A1 | Stable Granulates Containing S-adenosylmethionine and Process for Preparation Thereof | CHEMISTRY AND HEALTH INTERNATIONAL BV (CH) | 2008-11-06 | — | — | US | disclosed |
| WO-2007013987-A2 | SUPPLEMENT COMPOSITION AND METHOD OF USE IN ENHANCEMENT OF METHYLATION PROCESS | SURACELL, INC. (US) | 2007-02-01 | — | — | WO | disclosed |
| US-20070021376-A1 | Supplement composition and method of use in enhancement of methylation process | SURACELL, INC. (US) | 2007-01-25 | — | — | US | disclosed |
| US-20060275363-A1 | STABLE GRANULATES CONTAINING S-ADENOSYLMETHIONINE AND PROCESS FOR PREPARATION THEREOF | CHEMISTRY AND HEALTH INTERNATIONAL BV (CH) | 2006-12-07 | — | — | US | disclosed |
| US-7048948-B2 | Stable granulates containing S-adenosylmethionine and process for the preparation thereof | CHEMISTRY & HEALTH INTERNATIONAL BV (CH) | 2006-05-23 | — | — | US | disclosed |
| US-20040106573-A1 | Stable granulates containing s-adenosylmethionine and process for the preparation thereof | CHEMISTRY & HEALTH INTERNATIONAL BV (CH) | 2004-06-03 | — | — | US | disclosed |
| EP-1325740-B1 | Stable granulates containing S-Adenosylmethionine and process for the preparation thereof | CHEMISTRY & HEALTH INT BV (CH) | 2004-04-21 | — | — | EP | disclosed |
| EP-1325740-A1 | Stable granulates containing S-Adenosylmethionine and process for the preparation thereof | Chemistry & Health International B.V. (CH) | 2003-07-09 | — | — | EP | disclosed |
| WO-2003053412-A1 | STABLE GRANULATES CONTAINING S-ADENOSYLMETHIONNE AND PROCESS FOR THE PREPARATION THEREOF | CHEMISTRY & HEALTH INTERNATIONAL B.V. (CH) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140370108-A1 | Pharmacokinetics of S-Adenosylmethionine Formulations | MAT1A, MAT2A, AHCY | KDR 4222/4885CARM1 606/4885PRMT5 43/4885 |
| US-20240316089-A1 | COMBINATIONS FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS | GRIN3A, GRIN2A, GRIN2B | KDR 4197/4885CARM1 909/4885PRMT5 225/4885 |
| US-20080274997-A1 | Stable Granulates Containing S-adenosylmethionine and Process for Preparation Thereof | RNMT, BHMT2, MAT2A | KDR 2048/4885CARM1 277/4885PRMT5 88/4885 |
| US-20160361339-A1 | PHARMACOKINETICS OF S-ADENOSYLMETHIONINE FORMULATIONS | MAT1A, MAT2A, AHCY | KDR 4222/4885CARM1 606/4885PRMT5 43/4885 |
| US-20170027976-A1 | NOVEL ADEMETIONINE FORMULATIONS | BHMT2, MAT1A, BHMT | KDR 1925/4885CARM1 228/4885PRMT5 81/4885 |
| US-20040106573-A1 | Stable granulates containing s-adenosylmethionine and process for the preparation thereof | RNMT, BHMT2, GMPS | KDR 1950/4885CARM1 299/4885PRMT5 79/4885 |
| US-20060275363-A1 | STABLE GRANULATES CONTAINING S-ADENOSYLMETHIONINE AND PROCESS FOR PREPARATION THEREOF | RNMT, BHMT2, MAT2A | KDR 2048/4885CARM1 277/4885PRMT5 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.