Sugi Predict

Sugi Predict / Compounds / SCHEMBL126148

SCHEMBL126148

SCHEMBL126148

COC(=O)CC(=O)COCc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 5/20 0.55
▸ MAPT P10636 1/20 0.48
▸ ALDH1A1 P00352 6/20 0.47
▸ LMNA P02545 2/20 0.47
▸ KDM4E B2RXH2 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ RAB9A P51151 4/20 0.45
▸ MAPK1 P28482 1/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ SMN1; SMN2 Q16637 3/20 0.44
▸ GRM5 P41594 1/20 0.43
▸ HPGD P15428 1/20 0.42
▸ CSNK1D P48730 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18601228 0.97 NPC1 (0.52) NPC1MAPTALDH1A1LMNAKDM4E
SCHEMBL1171919 0.87 TSHR (0.52) NPC1MAPTALDH1A1LMNAKDM4E
SCHEMBL6702666 0.87 TSHR (0.56) NPC1MAPTALDH1A1LMNATSHR
SCHEMBL11525397 0.86 ALDH1A1 (0.58) NPC1ALDH1A1LMNATSHRRAB9A
SCHEMBL53331 0.85 PPID (0.49) NPC1MAPTALDH1A1LMNATSHR
SCHEMBL7231280 0.85 ALDH1A1 (0.45) NPC1MAPTALDH1A1LMNATSHR
SCHEMBL6568404 0.85 RAB9A (0.49) NPC1MAPTALDH1A1LMNARAB9A
SCHEMBL9622282 0.84 NPC1 (0.52) NPC1MAPTALDH1A1LMNATSHR
SCHEMBL4545478 0.84 PPARA (0.48) NPC1MAPTALDH1A1TSHRRAB9A
SCHEMBL135319 0.84 TSHR (0.57) NPC1MAPTALDH1A1TSHRRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117736225-A Continuous preparation method of dorterevir 华东理工大学 2024-03-22 — — CN claimed
EP-0912467-B1 ASYMMETRIC HYDROGENATION METHOD OF A KETONIC COMPOUND AND DERIVATIVE RHODIA CHIMIE SA (FR) 2002-04-24 — — EP claimed
CN-117736225-A Continuous preparation method of dorterevir 华东理工大学 2024-03-22 — — CN disclosed
CN-111491935-B Novel analogs as modulators of androgen and glucocorticoid receptors 昂科斯特拉公司 2023-08-22 — — CN disclosed
EP-3707143-B9 NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS ONCOSTELLAE S L (ES) 2023-04-12 — — EP disclosed
EP-3707143-B1 NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS ONCOSTELLAE S L (ES) 2022-12-28 — — EP disclosed
US-11453660-B2 Androgen receptor and glucocorticoid receptor modulators ONCOSTELLAE, S.L. 2022-09-27 — — US disclosed
US-20210147428-A1 METHOD FOR PREPARING PYRROLOAMINOPYRIDAZINONE COMPOUND AND INTERMEDIATES THEREOF JIANGSU HENGRUI MEDICINE CO., LTD. (CN) 2021-05-20 — — US disclosed
CN-107778273-B Synthesis method of pyrone compound 广东莱佛士制药技术有限公司 2021-05-18 — — CN disclosed
EP-3778591-A1 METHOD FOR PREPARING PYRROLOAMINOPYRIDAZINONE COMPOUND AND INTERMEDIATES THEREOF Jiangsu Hengrui Medicine Co., Ltd. (CN) 2021-02-17 — — EP disclosed
US-20200339565-A1 PRODRUG SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE SHIONOGI & CO., LTD. (JP) 2020-10-29 — — US disclosed
US-20030105341-A1 Process for producing optically active gamma-butyrolactone TAKASAGO INTERNATIONAL CORPORATION (JP) 2003-06-05 — — US disclosed
EP-1277748-A1 Process for producing optically active y-Butyrolactone Takasago International Corporation (JP) 2003-01-22 — — EP disclosed
US-6492545-B2 Process for producing optically active alcohol TAKASAGO INTERNATIONAL CORPORATION (JP) 2002-12-10 — — US disclosed
US-20020035283-A1 Process for producing optically active alcohol TAKASAGO INTERNATIONAL CORPORATION 2002-03-21 — — US disclosed
EP-1176135-A1 Process for producing optically active alcohol Takasago International Corporation (JP) 2002-01-30 — — EP disclosed
US-6166257-A METAL COMPLEX OF AN OPTICALLY ACTIVE BIS(1-PHOSPHA-2,3-DIPHENYL-4,5-DIMETHYLNORBORNADIENE) RHODIA CHIMIE (FR) 2000-12-26 — — US disclosed
EP-0295109-B2 Process for preparing optically active alcohol TAKASAGO PERFUMERY CO LTD (JP) 1996-09-04 — — EP disclosed
US-4933482-A HYDROGENATION OF BETA-KETO ACID IN PRESENCE OF RUTHENIUM PHOSPHINE COMPLEX TAKASAGO INTERNATIONAL CORPORATION (JP) 1990-06-12 — — US disclosed
EP-0295109-A1 Process for preparing optically active alcohol Takasago International Corporation (JP) 1988-12-14 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030105341-A1 Process for producing optically active gamma-butyrolactone HSD17B10, HSD17B1, HSD17B12 NPC1 4560/4885MAPT 2971/4885ALDH1A1 77/4885
US-20200339565-A1 PRODRUG SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PREP, UNG, DPP4 NPC1 3129/4885MAPT 4579/4885ALDH1A1 1478/4885
US-20210147428-A1 METHOD FOR PREPARING PYRROLOAMINOPYRIDAZINONE COMPOUND AND INTERMEDIATES THEREOF DHPS, PPOX, PNPO NPC1 3809/4885MAPT 3800/4885ALDH1A1 441/4885
US-20020035283-A1 Process for producing optically active alcohol ADH1A, ADH5, ADH1C NPC1 3437/4885MAPT 3700/4885ALDH1A1 38/4885
US-11453660-B2 Androgen receptor and glucocorticoid receptor modulators AR, NR5A1, NR3C1 NPC1 2949/4885MAPT 2678/4885ALDH1A1 1496/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.