Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628821 | 0.83 | MAPT (0.37) | MAPTTP53ALDH1A1TSHRHSD17B10 | |
| SCHEMBL13628846 | 0.80 | POLB (0.41) | TP53ALDH1A1NPSR1HPGDLMNA | |
| SCHEMBL2926901 | 0.79 | PTGS2 (0.47) | MAPTTP53ALDH1A1TSHRHSD17B10 | |
| SCHEMBL13628858 | 0.75 | CCR2 (0.38) | MAPTTP53TSHRNPSR1CYP1A2 | |
| SCHEMBL13628859 | 0.74 | PTGS2 (0.45) | TP53TBXA2RPOLB | |
| SCHEMBL13628860 | 0.73 | PTGS2 (0.46) | MAPTTP53LMNATBXA2R | |
| SCHEMBL13628851 | 0.71 | PTGS2 (0.36) | TP53ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL13628847 | 0.71 | CYP11B2 (0.43) | MAPTNPSR1 | |
| SCHEMBL13628853 | 0.70 | PTGS2 (0.37) | MAPTALDH1A1TSHRKMT2ANPSR1 | |
| SCHEMBL13628824 | 0.69 | RAB9A (0.36) | MAPTALDH1A1TSHRMAPK1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612070-B2 | Heterocyclic compounds as antiinflammatory agents and cyclooxygenase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-11-03 | — | — | US | disclosed |