Sugi Predict

Sugi Predict / Compounds / SCHEMBL13737248

SCHEMBL13737248

SCHEMBL13737248

Fc1ccc2nc3cc(Cl)ccc3c(Cl)c2c1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ DHODH Q02127 3/20 0.44
▸ MAOA P21397 1/20 0.42
▸ MAOB P27338 1/20 0.42
▸ POLB P06746 1/20 0.42
▸ ESR1 P03372 1/20 0.42
▸ ESR2 Q92731 1/20 0.42
▸ MEN1 O00255 2/20 0.42
▸ KMT2A Q03164 2/20 0.42
▸ KDM4E B2RXH2 1/20 0.40
▸ SOS1 Q07889 1/20 0.40
▸ NR4A2 P43354 1/20 0.40
▸ BCHE P06276 2/20 0.39
▸ ACHE P22303 2/20 0.39
▸ GRIN1 Q05586 2/20 0.39
▸ GRIN2A Q12879 2/20 0.39
▸ CASP3 P42574 1/20 0.39
▸ MPO P05164 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31500251 0.89 MAOA (0.52) MAOAMAOBPOLBESR1ESR2
SCHEMBL17423119 0.83 POLB (0.55) MAOAMAOBPOLBESR1ESR2
SCHEMBL31500224 0.83 MAOA (0.58) MAOAMAOBKDM4ENR4A2BCHE
SCHEMBL22791812 0.79 LMNA (0.50) DHODHMAOAMAOBPOLBESR1
SCHEMBL9709249 0.78 MAOA (0.72) MAOAMAOBPOLBESR1ESR2
SCHEMBL72366 0.77 ADORA3 (0.45) DHODHNR4A2BCHEACHEGRIN1
SCHEMBL7875727 0.76 MEN1 (0.56) MEN1KMT2ABCHEACHE
SCHEMBL11780381 0.76 MAOA (0.75) MAOAMAOBPOLBKMT2AKDM4E
SCHEMBL31038657 0.76 KDM4E (0.68) POLBMEN1KMT2AKDM4EACHE
SCHEMBL2448633 0.76 KDM4E (0.68) POLBMEN1KMT2AKDM4EACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10544100-B2 Autophagy inhibitors TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2020-01-28 — — US disclosed
US-20180290980-A1 Autophagy Inhibitors VAN ANDEL RESEARCH INSTITUTE 2018-10-11 — — US disclosed
US-20170000784-A1 Autophagy Inhibitors VAN ANDEL RESEARCH INSTITUTE 2017-01-05 — — US disclosed
US-20160137607-A1 Autophagy Inhibitors VAN ANDEL RESEARCH INSTITUTE 2016-05-19 — — US disclosed
US-9221760-B2 Autophagy inhibitors VAN ANDEL RESEARCH INSTITUTE (US) 2015-12-29 — — US disclosed
WO-2015085229-A1 AUTOPHAGY INHIBITORS VAN ANDEL RESEARCH INSTITUTE (US) 2015-06-11 — — WO disclosed
US-20140148451-A1 Autophagy Inhibitors TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2014-05-29 — — US disclosed
WO-2012154879-A2 AUTOPHAGY INHIBITORS VAN ANDEL RESEARCH INSTITUTE (US) 2012-11-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10544100-B2 Autophagy inhibitors BECN1, ATG7, SQSTM1 DHODH 3185/4885MAOA 2860/4885MAOB 2729/4885
US-20170000784-A1 Autophagy Inhibitors BRAF, HRAS, NRAS DHODH 3439/4885MAOA 3137/4885MAOB 4442/4885
US-20140148451-A1 Autophagy Inhibitors BECN1, ATG7, SQSTM1 DHODH 3185/4885MAOA 2860/4885MAOB 2729/4885
US-20160137607-A1 Autophagy Inhibitors BECN1, ATG7, SQSTM1 DHODH 3185/4885MAOA 2860/4885MAOB 2729/4885
US-20180290980-A1 Autophagy Inhibitors BECN1, ATG7, SQSTM1 DHODH 3185/4885MAOA 2860/4885MAOB 2729/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.