SCHEMBL143807

SCHEMBL143807

Sc1nnc(-c2ccccc2)[nH]1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.52
RAB9A P51151 3/20 0.52
POLB P06746 2/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
NPY5R Q15761 2/20 0.42
SCN2A Q99250 1/20 0.42
BTK Q06187 1/20 0.42
GAA P10253 3/20 0.41
MTOR P42345 1/20 0.39
ADK P55263 1/20 0.39
NISCH Q9Y2I1 1/20 0.39
MAPK1 P28482 2/20 0.39
DCUN1D1 Q96GG9 2/20 0.38
NR1H2 P55055 1/20 0.38
NR1H3 Q13133 1/20 0.38
PIN1 Q13526 2/20 0.37
TNKS O95271 1/20 0.37
PARP1 P09874 1/20 0.37
TNKS2 Q9H2K2 1/20 0.37
ALDH1A1 P00352 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12716533 0.84 NPC1 (0.37) NPC1RAB9APOLBL3MBTL1SCN2A
SCHEMBL384952 0.83 NPC1 (0.61) NPC1RAB9APOLBL3MBTL1NPY5R
SCHEMBL24317555 0.80 NPC1 (0.59) NPC1RAB9APOLBL3MBTL1NPY5R
SCHEMBL912607 0.80 MAPT (0.42) NPC1RAB9ANPY5RGAAALDH1A1
SCHEMBL14424582 0.78 NISCH (0.42) NPC1RAB9APOLBL3MBTL1NISCH
SCHEMBL3987498 0.78 MAPT (0.43) NPC1RAB9APOLBGAATNKS
SCHEMBL17541733 0.78 NPC1 (0.42) NPC1RAB9APOLBGAATNKS
SCHEMBL31429116 0.78 MAPK13 (0.40) MAPK1NR1H2NR1H3TNKSPARP1
SCHEMBL5638065 0.78 KDM4E (0.41) NPC1RAB9APOLBSCN2AGAA
SCHEMBL17948203 0.78 NPC1 (0.57) NPC1RAB9APOLBL3MBTL1NPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260107722-A1 TOOLS FOR CHEMICAL PLANARIZATION CHEMPOWER CORP (US) 2026-04-16 US disclosed
US-12593637-B2 Chemical planarization CHEMPOWER CORPORATION (US) 2026-03-31 US disclosed
US-20260061548-A1 PAD SURFACE REGENERATION AND METAL RECOVERY CHEMPOWER CORP (US) 2026-03-05 US disclosed
CN-121586633-A Pad for chemical planarization 肯珀尔公司 2026-02-27 CN disclosed
US-12500088-B2 Tools for chemical planarization CHEMPOWER CORPORATION (US) 2025-12-16 US disclosed
US-12466025-B2 Pad surface regeneration and metal recovery CHEMPOWER CORPORATION (US) 2025-11-11 US disclosed
US-20250091176-A1 CHEMICAL PLANARIZATION OF NON-METALLIC MATERIALS CHEMPOWER CORPORATION 2025-03-20 US disclosed
CN-119350258-A Perilla alcohol-1, 2, 4-triazole thioether derivative, and preparation method and application thereof 南宁师范大学 2025-01-24 CN disclosed
US-20240391050-A1 PADS FOR CHEMICAL PLANARIZATION CHEMPOWER CORPORATION 2024-11-28 US disclosed
CN-118434537-A Tool for chemical planarization 化学动力公司 2024-08-02 CN disclosed
EP-1372655-A4 CATHEPSIN CYSTEINE PROTEASE INHIBITORS MERCK FROSST CANADA INC (CA) 2005-10-12 EP disclosed
US-20040198982-A1 Cathepsin cysteine protease inhibitors MERCK CANADA INC. (CA) 2004-10-07 US disclosed
EP-1372655-A2 CATHEPSIN CYSTEINE PROTEASE INHIBITORS Merck Frosst Canada & Co. (CA) 2004-01-02 EP disclosed
WO-2002069901-A2 CATHEPSIN CYSTEINE PROTEASE INHIBITORS MERCK FROSST CANADA & CO. (CA) 2002-09-12 WO disclosed
US-5939462-A ADMINISTERING ALKOXY AND -THIOALKOXYAMIDE COMPOSITIONS TO MAMMALS TO TREAT DISORDERS SUCH AS OBESITY THAT ARE MEDIATED BY NEUROPEPTIDE Y (?NPY?) BAYER CORPORATION (US) 1999-08-17 US disclosed
US-RE35754-E FOR TREATING BACTERIAL INFECTIONS HOECHST AKTIENGESELLSCHAFT (DE) 1998-03-24 US disclosed
US-5710146-A ANTIBIOTICS FOR BACTERICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1998-01-20 US disclosed
US-5089490-A Cephem derivatives HOECHST AKTIENGESELLSCHAFT (DE) 1992-02-18 US disclosed
US-4758556-A Cephem derivatives HOECHST AKTIENGESELLSCHAFT (DE) 1988-07-19 US disclosed
US-4278793-A ANTIBIOTICS, BACTERICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1981-07-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040198982-A1 Cathepsin cysteine protease inhibitors CTSB, CTSS, CTSZ NPC1 287/4885RAB9A 477/4885POLB 3196/4885
US-12593637-B2 Chemical planarization PPOX, GPX4, DUOX1 NPC1 1741/4885RAB9A 2631/4885POLB 3784/4885
US-20260107722-A1 TOOLS FOR CHEMICAL PLANARIZATION FZD7, PIEZO1, CDH1 NPC1 1658/4885RAB9A 3527/4885POLB 4149/4885
US-20260061548-A1 PAD SURFACE REGENERATION AND METAL RECOVERY PADI4, PADI2, PADI1 NPC1 2888/4885RAB9A 2674/4885POLB 2039/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.