SCHEMBL146386

SCHEMBL146386

O=C(O)c1cccc(Br)c1F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRNP P04156 1/20 0.50
ALB P02768 1/20 0.50
ALDH1A1 P00352 5/20 0.48
ALOX15 P16050 1/20 0.48
FABP4 P15090 1/20 0.45
CA12 O43570 2/20 0.44
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
CA4 P22748 2/20 0.44
CA7 P43166 2/20 0.44
CA9 Q16790 2/20 0.44
NAPRT Q6XQN6 2/20 0.44
CES2 O00748 1/20 0.43
BCHE P06276 1/20 0.43
CES1 P23141 1/20 0.43
KDM4E B2RXH2 3/20 0.42
ASPH Q12797 1/20 0.42
KDM8 Q8N371 1/20 0.42
KMT2A Q03164 1/20 0.42
TSHR P16473 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29570698 1.00 PRNP (0.50) PRNPALBALDH1A1ALOX15FABP4
SCHEMBL17375418 0.91 ALB (0.52) PRNPALBALDH1A1ALOX15FABP4
SCHEMBL336107 0.84 ALDH1A1 (0.60) ALBALDH1A1ALOX15CA12CA1
SCHEMBL28290974 0.83 CES2 (0.50) PRNPALBALDH1A1ALOX15FABP4
SCHEMBL9217406 0.83 CES2 (0.43) PRNPALBALDH1A1ALOX15CES2
SCHEMBL11135091 0.83 CES2 (0.43) PRNPALBALDH1A1ALOX15CES2
SCHEMBL145431 0.81 DGAT1 (0.46) ALDH1A1CES2BCHECES1KDM4E
SCHEMBL147599 0.81 ALDH1A1 (0.52) PRNPALBALDH1A1ALOX15CES2
SCHEMBL31184721 0.81 ALDH1A1 (0.52) PRNPALBALDH1A1ALOX15CES2
SCHEMBL1849109 0.81 CES2 (0.42) PRNPALDH1A1CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 684 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108084013-B Synthetic method of 3-bromo-2-fluorobenzoic acid 蓬莱市前卫化工有限公司 2020-09-01 CN claimed
WO-2018057219-A1 METHOD OF ALLOCATING INDIVIDUAL OIL OR WATER PRODUCTION CONTRIBUTIONS FROM MULTIPLE COMBINED SOURCES SPECTRUM TRACER SERVICES, LLC (US) 2018-03-29 WO claimed
US-20180080314-A1 METHOD OF ALLOCATING INDIVIDUAL OIL OR WATER PRODUCTION CONTRIBUTIONS FROM MULTIPLE COMBINED SOURCES SPECTRUM TRACER SERVICES, LLC 2018-03-22 US claimed
CN-103382187-B 3-chloro-7(5)-bromo-benzo-isoxazole compounding method SYNTHESIS MED SHANGHAI CO LTD 2015-06-03 CN claimed
CN-103382187-A 3-chloro-7(5)-bromo-benzo-isoxazole compounding method SYNTHESIS MED SHANGHAI CO LTD 2013-11-06 CN claimed
US-20260138956-A1 NOVEL COMPOUNDS AND USES THEREOF RECURSION PHARMACEUTICALS INC (US) 2026-05-21 US disclosed
US-12622909-B2 Allosteric EGFR inhibitors and methods of use thereof DANA-FARBER CANCER INSTITUTE, INC. (US) 2026-05-12 US disclosed
US-12458627-B2 Autotaxin inhibitors and uses thereof DF 2024 IP ACQUISITION, LLC (US) 2025-11-04 US disclosed
US-20250214986-A1 P2X3 INHIBITOR COMPOUND, SALT THEREOF, POLYMORPH THEREOF AND USE THEREOF HUMANWELL HEATHCARE (GROUP) CO., LTD. (CN) 2025-07-03 US disclosed
CN-120152713-A Tricyclic aryl derivatives and compositions and methods thereof 昂胜医疗科技公司 2025-06-13 CN disclosed
EP-4561562-A2 TRICYCLIC ARYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF Ensem Therapeutics, Inc. (US) 2025-06-04 EP disclosed
EP-4559918-A2 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS Genzyme Corporation (US) 2025-05-28 EP disclosed
WO-2001087845-A2 N-CONTAINING HETEROCYCLIC COMPOUNDS AND THEIR USE AS 5-HT ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-11-22 WO disclosed
US-6284755-B1 Inhibitors of prenyl-protein transferase MERCK & CO., INC. 2001-09-04 US disclosed
WO-2000066167-A1 CONTRACEPTIVE COMPOSITIONS CONTAINING INDOLINE DERIVATIVES AND PROGESTATIONAL AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 WO disclosed
WO-2000066556-A1 INDOLINE DERIVATIVES AS PROGESTERONE ANTAGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 WO disclosed
WO-2000066571-A1 CYCLOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 WO disclosed
WO-2000066164-A1 CONTRACEPTIVE COMPOSITIONS CONTAINING ANTIPROGESTINIC AND PROGESTINIC AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 WO disclosed
WO-2000059930-A1 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 2000-10-12 WO disclosed
US-4386035-A INSECTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1983-05-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260138956-A1 NOVEL COMPOUNDS AND USES THEREOF SLC10A1, NR3C2, CYP2C8 PRNP 2682/4885ALB 3027/4885ALDH1A1 230/4885
US-20250214986-A1 P2X3 INHIBITOR COMPOUND, SALT THEREOF, POLYMORPH THEREOF AND USE THEREOF P2RX3, P2RX6, P2RX7 PRNP 1266/4885ALB 3140/4885ALDH1A1 967/4885
US-12622909-B2 Allosteric EGFR inhibitors and methods of use thereof EGFR, ERBB3, ERBB2 PRNP 4603/4885ALB 4290/4885ALDH1A1 4245/4885
US-12458627-B2 Autotaxin inhibitors and uses thereof ENPP2, SERPINB1, RNASE1 PRNP 612/4885ALB 1195/4885ALDH1A1 4716/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.