SCHEMBL14740699

SCHEMBL14740699

CS[C@H]1O[C@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.49
KDM4E B2RXH2 3/20 0.45
ALDH1A1 P00352 3/20 0.45
HPGD P15428 3/20 0.45
LMNA P02545 3/20 0.45
MAPT P10636 2/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
CA12 O43570 9/20 0.43
CA1 P00915 9/20 0.43
CA2 P00918 9/20 0.43
CA4 P22748 3/20 0.43
CA5A P35218 3/20 0.43
CA7 P43166 3/20 0.43
CA5B Q9Y2D0 3/20 0.43
CA9 Q16790 6/20 0.41
PARP1 P09874 1/20 0.40
PKM P14618 1/20 0.40
KMT2A Q03164 1/20 0.38
P4HB P07237 1/20 0.38
PTPN1 P18031 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14278404 0.84 TSHR (0.52) TSHRALDH1A1LMNACA12CA1
SCHEMBL2454848 0.84 TSHR (0.52) TSHRALDH1A1LMNACA12CA1
SCHEMBL2454844 0.84 TSHR (0.52) TSHRALDH1A1LMNACA12CA1
SCHEMBL7025660 0.83 TSHR (0.51) TSHRKDM4EALDH1A1HPGDLMNA
SCHEMBL6303221 0.83 TSHR (0.71) TSHRKDM4EALDH1A1HPGDLMNA
SCHEMBL21753464 0.83 TSHR (0.51) TSHRKDM4EALDH1A1HPGDLMNA
SCHEMBL18343982 0.82 TSHR (0.50) TSHRALDH1A1LMNAKMT2AP4HB
SCHEMBL9393500 0.82 TSHR (0.50) TSHRALDH1A1LMNAKMT2AP4HB
SCHEMBL6297105 0.81 TSHR (0.48) TSHRKDM4EALDH1A1HPGDLMNA
SCHEMBL20095195 0.80 TSHR (0.59) TSHRALDH1A1LMNACA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 267 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240200076-A1 NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, PREPARATION METHOD, AND USE Suzhou Ribo Life Science Co., Ltd. (CN) 2024-06-20 US claimed
US-11918600-B2 Nucleic acid, pharmaceutical composition and conjugate containing nucleic acid, and use thereof Suzhou Ribo Life Science Co., Ltd. (CN) 2024-03-05 US claimed
US-20230313195-A1 NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, PREPARATION METHOD, AND USE Suzhou Ribo Life Science Co., Ltd. (CN) 2023-10-05 US claimed
US-20230257827-A1 CONJUGATES AND PREPARATION AND USE THEREOF Suzhou Ribo Life Science Co., Ltd. (CN) 2023-08-17 US claimed
US-20230193277-A1 NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, PREPARATION METHOD, AND USE Suzhou Ribo Life Science Co., Ltd. (CN) 2023-06-22 US claimed
US-11660347-B2 Nucleic acid, composition and conjugate containing same, preparation method, and use thereof Suzhou Ribo Life Science Co., Ltd. (CN) 2023-05-30 US claimed
US-20230076803-A1 COMPOUND AND DRUG CONJUGATE, AND PREPARATION METHOD AND USE THEREOF Suzhou Ribo Life Science Co., Ltd. (CN) 2023-03-09 US claimed
US-20220395526-A1 NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING SAME, AND PREPARATION METHOD AND USE Suzhou Ribo Life Science Co., Ltd. (CN) 2022-12-15 US claimed
EP-4023659-A1 COMPOUND AND DRUG CONJUGATE, AND PREPARATION METHOD AND USE THEREOF Suzhou Ribo Life Science Co., Ltd. (CN) 2022-07-06 EP claimed
EP-3974532-A1 NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, PREPARATION METHOD, AND USE Suzhou Ribo Life Science Co., Ltd. (CN) 2022-03-30 EP claimed
EP-3719125-A1 NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING SAME, AND PREPARATION METHOD AND USE Suzhou Ribo Life Science Co., Ltd. (CN) 2020-10-07 EP claimed
EP-3719127-A1 NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING SAME, PREPARATION METHOD, AND USE Suzhou Ribo Life Science Co., Ltd. (CN) 2020-10-07 EP claimed
EP-3137604-A2 COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION Ionis Pharmaceuticals, Inc. (US) 2017-03-08 EP claimed
EP-3137091-A2 COMPOSITIONS AND METHODS FOR MODULATING PKK EXPRESSION Ionis Pharmaceuticals, Inc. (US) 2017-03-08 EP claimed
EP-3137605-A2 COMPOSITIONS AND METHODS FOR MODULATING ANGIOPOIETIN-LIKE 3 EXPRESSION Ionis Pharmaceuticals, Inc. (US) 2017-03-08 EP claimed
US-20160076032-A1 COMPOSITIONS AND METHODS ISIS PHARMACEUTICALS, INC. (US) 2016-03-17 US claimed
WO-2015168532-A2 COMPOSITIONS AND METHODS FOR MODULATING PKK EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2015-11-05 WO claimed
WO-2015168618-A2 COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2015-11-05 WO claimed
EP-2751270-A1 OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE Isis Pharmaceuticals, Inc. (US) 2014-07-09 EP claimed
WO-2013033230-A1 OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE ISIS PHARMACEUTICALS, INC. (US) 2013-03-07 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11918600-B2 Nucleic acid, pharmaceutical composition and conjugate containing nucleic acid, and use thereof NSUN2, SLC10A1, BCDIN3D TSHR 2222/4885KDM4E 2535/4885ALDH1A1 3651/4885
US-20220395526-A1 NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING SAME, AND PREPARATION METHOD AND USE NSUN2, RNGTT, ADAR TSHR 3668/4885KDM4E 2673/4885ALDH1A1 3468/4885
US-20240200076-A1 NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, PREPARATION METHOD, AND USE PNP, NTPCR, RNASE1 TSHR 2783/4885KDM4E 4158/4885ALDH1A1 1228/4885
US-11660347-B2 Nucleic acid, composition and conjugate containing same, preparation method, and use thereof APOB, C1QBP, APOL1 TSHR 3909/4885KDM4E 3824/4885ALDH1A1 3395/4885
US-20230193277-A1 NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, PREPARATION METHOD, AND USE F13A1, F13B, F11 TSHR 3090/4885KDM4E 3618/4885ALDH1A1 3143/4885
US-20230076803-A1 COMPOUND AND DRUG CONJUGATE, AND PREPARATION METHOD AND USE THEREOF ABCG2, ABCB1, SLC10A1 TSHR 3201/4885KDM4E 3118/4885ALDH1A1 278/4885
US-20160076032-A1 COMPOSITIONS AND METHODS FUT6, FUT5, GNE TSHR 4110/4885KDM4E 3543/4885ALDH1A1 1681/4885
US-20230313195-A1 NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, PREPARATION METHOD, AND USE PCSK9, PCSK7, PCSK6 TSHR 4123/4885KDM4E 1680/4885ALDH1A1 4386/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.