Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 known ✓ | P11387 | 4/20 | 0.55 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.68 |
| ▸ | TERT | O14746 | 5/20 | 0.66 |
| ▸ | CYCS | P99999 | 3/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17768420 | 0.98 | ENPP2 (0.70) | ENPP2TERTTOP1CYCSABCG2 | |
| Water SCHEMBL8810288 | 0.97 | ENPP2 (0.68) | ENPP2TERTTOP1CYCSABCG2 | |
| SCHEMBL498417 | 0.95 | ENPP2 (0.70) | ENPP2TERTTOP1CYCSABCG2 | |
| SCHEMBL9267975 | 0.95 | TERT (0.71) | ENPP2TERTTOP1CYCSABCG2 | |
| SCHEMBL8994427 | 0.95 | ENPP2 (0.70) | ENPP2TERTTOP1CYCSABCG2 | |
| SCHEMBL23706379 | 0.95 | ENPP2 (0.70) | ENPP2TERTTOP1CYCSABCG2 | |
| SCHEMBL6139711 | 0.95 | ENPP2 (0.70) | ENPP2TERTTOP1CYCSABCG2 | |
| SCHEMBL5051415 | 0.95 | ENPP2 (0.70) | ENPP2TERTTOP1CYCSABCG2 | |
| Zinc Ion SCHEMBL11569891 | 0.95 | ENPP2 (0.70) | ENPP2TERTTOP1CYCSABCG2 | |
| SCHEMBL2334465 | 0.95 | ENPP2 (0.70) | ENPP2TERTTOP1CYCSABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250144021-A1 | GEL FORMULATIONS FOR LOCAL DRUG RELEASE | TECHNICAL UNIVERSITY OF DENMARK (DK) | 2025-05-08 | — | — | US | disclosed |
| EP-4529477-A1 | POROUS EXPANDING BIOCOMPATIBLE SCAFFOLDS | Danmarks Tekniske Universitet (DK) | 2025-04-02 | — | — | EP | disclosed |
| US-12226527-B2 | Gel formulations for local drug release | TECHNICAL UNIVERSITY OF DENMARK (DK) | 2025-02-18 | — | — | US | disclosed |
| WO-2023227518-A1 | POROUS EXPANDING BIOCOMPATIBLE SCAFFOLDS | DANMARKS TEKNISKE UNIVERSITET (DK) | 2023-11-30 | — | — | WO | disclosed |
| WO-2023227517-A1 | FORMULATION OF API'S AND EXCIPIENT'S IN AN ICELL VIA HYDROPHOBIC ION PAIRING | DANMARKS TEKNISKE UNIVERSITET (DK) | 2023-11-30 | — | — | WO | disclosed |
| EP-4282448-A1 | POROUS EXPANDING BIOCOMPATIBLE SCAFFOLDS | Danmarks Tekniske Universitet (DK) | 2023-11-29 | — | — | EP | disclosed |
| EP-4282435-A1 | FORMULATIONS OF ACTIVE PHARMACEUTICAL INGREDIENTS AND EXCIPIENTS IN ICELLS VIA HYDROPHOBIC ION PAIRING | Danmarks Tekniske Universitet (DK) | 2023-11-29 | — | — | EP | disclosed |
| US-20220339285-A1 | DISSACHARIDE FORMULATIONS FOR CONTROLLED DRUG RELEASE | TECHNICAL UNIVERSITY OF DENMARK (DK) | 2022-10-27 | — | — | US | disclosed |
| EP-3982922-A1 | DISSACHARIDE FORMULATIONS FOR CONTROLLED DRUG RELEASE | Technical University of Denmark (DK) | 2022-04-20 | — | — | EP | disclosed |
| US-20210386669-A1 | GEL FORMULATIONS FOR LOCAL DRUG RELEASE | TECHNICAL UNIVERSITY OF DENMARK (DK) | 2021-12-16 | — | — | US | disclosed |
| US-20180339068-A1 | Formulation of Solid Nano-Sized Particles in a Gel-Forming System | DANMARKS TEKNISKE UNIVERSITET (DK) | 2018-11-29 | — | — | US | disclosed |
| US-20180325819-A1 | GEL FORMULATIONS FOR LOCAL DRUG RELEASE | TECHNICAL UNIVERSITY OF DENMARK (DK) | 2018-11-15 | — | — | US | disclosed |
| US-10064960-B2 | Formulation of solid nano-sized particles in a gel-forming system | DANMARKS TEKNISKE UNIVERSITET (DK) | 2018-09-04 | — | — | US | disclosed |
| WO-2016079332-A1 | GEL FORMULATIONS FOR IMPROVING IMMUNOTHERAPY | TECHNICAL UNIVERSITY OF DENMARK (DK) | 2016-05-26 | — | — | WO | disclosed |
| EP-3003397-A1 | GEL FORMULATIONS FOR GUIDING RADIOTHERAPY | Danmarks Tekniske Universitet (DTU) (DK) | 2016-04-13 | — | — | EP | disclosed |
| US-20160089454-A1 | GEL FORMULATIONS FOR GUIDING RADIOTHERAPY | DANMARKS TEKNISKE UNIVERSITET (DK) | 2016-03-31 | — | — | US | disclosed |
| WO-2014187962-A1 | GEL FORMULATIONS FOR GUIDING RADIOTHERAPY | DANMARKS TEKNISKE UNIVERSITET (DK) | 2014-11-27 | — | — | WO | disclosed |
| US-20140343413-A1 | FORMULATION OF SOLID NANO-SIZED PARTICLES IN A GEL-FORMING SYSTEM | DANMARKS TEKNISKE UNIVERSITET (DK) | 2014-11-20 | — | — | US | disclosed |
| EP-2782603-A1 | FORMULATION OF SOLID NANO-SIZED PARTICLES IN A GEL-FORMING SYSTEM | Danmarks Tekniske Universitet (DK) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013076305-A1 | FORMULATION OF SOLID NANO-SIZED PARTICLES IN A GEL-FORMING SYSTEM | DANMARKS TEKNISKE UNIVERSITET (DK) | 2013-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180325819-A1 | GEL FORMULATIONS FOR LOCAL DRUG RELEASE | TREH, GALE, SLC2A8 | TOP1 1369/4885ENPP2 1180/4885TERT 4696/4885 |
| US-20250144021-A1 | GEL FORMULATIONS FOR LOCAL DRUG RELEASE | TREH, GALE, SLC2A8 | TOP1 1369/4885ENPP2 1180/4885TERT 4696/4885 |
| US-20210386669-A1 | GEL FORMULATIONS FOR LOCAL DRUG RELEASE | TREH, GALE, SLC2A8 | TOP1 1369/4885ENPP2 1180/4885TERT 4696/4885 |
| US-12226527-B2 | Gel formulations for local drug release | TREH, GALE, SLC2A8 | TOP1 1369/4885ENPP2 1180/4885TERT 4696/4885 |
| US-20220339285-A1 | DISSACHARIDE FORMULATIONS FOR CONTROLLED DRUG RELEASE | LIPA, LIPE, CEL | TOP1 2058/4885ENPP2 2532/4885TERT 3512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.