Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.56 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.51 |
| ▸ | WNT3A | P56704 | 2/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | TPMT | P51580 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462140 | 0.86 | GSK3B (0.56) | GSK3BCTNNB1WNT3ATAS1R3TAS1R1 | |
| SCHEMBL29620831 | 0.86 | TSHR (0.63) | GSK3BCTNNB1WNT3ATSHRMAPT | |
| SCHEMBL426444 | 0.86 | TSHR (0.63) | GSK3BCTNNB1WNT3ATSHRMAPT | |
| SCHEMBL15965403 | 0.84 | MEN1 (0.60) | CTNNB1WNT3ATAS1R3TAS1R1TSHR | |
| SCHEMBL15965424 | 0.84 | CTNNB1 (0.53) | CTNNB1WNT3ATAS1R3TAS1R1TSHR | |
| SCHEMBL5050071 | 0.83 | GSK3B (0.49) | GSK3BTAS1R3TAS1R1TSHRPTPN1 | |
| SCHEMBL19318659 | 0.83 | GSK3B (0.56) | GSK3BCTNNB1WNT3ATSHRMAPT | |
| SCHEMBL12937549 | 0.83 | CTNNB1 (0.51) | CTNNB1WNT3ATAS1R3TAS1R1TSHR | |
| SCHEMBL11335265 | 0.83 | MAPT (0.55) | CTNNB1WNT3ATAS1R3TAS1R1TSHR | |
| SCHEMBL1119567 | 0.83 | MEN1 (0.66) | GSK3BTSHRMAPTCYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358962-B2 | 2-hetaryl imidazol[1,2-a]pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2022-06-14 | — | — | US | disclosed |
| US-11147884-B2 | Inhibitors of NHE-mediated antiport | ARDELYX, INC. (US) | 2021-10-19 | — | — | US | disclosed |
| US-10975073-B2 | Imaging methods using 2-hetaryl imidazol[1,2-a]pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20190048003-A1 | 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2019-02-14 | — | — | US | disclosed |
| US-20190048002-A1 | 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2019-02-14 | — | — | US | disclosed |
| US-10138234-B2 | 2-phenyl or 2-hetaryl imidazol[1,2-a]pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2018-11-27 | — | — | US | disclosed |
| US-9801961-B2 | 2-phenylimidazo[1,2-a]pyrimidines as imaging agents | HOFFMANN-LA ROCHE INC. (US) | 2017-10-31 | — | — | US | disclosed |
| US-20170128598-A1 | 2-PHENYLIMIDAZO[1,2-A]PYRIMIDINES AS IMAGING AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2017-05-11 | — | — | US | disclosed |
| EP-2999701-B1 | 2-PHENYLIMIDAZO[1,2-A]PYRIMIDINES AS IMAGING AGENTS | HOFFMANN LA ROCHE (US) | 2017-04-12 | — | — | EP | disclosed |
| EP-2991983-B1 | 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-A]PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-03-01 | — | — | EP | disclosed |
| US-20160244441-A1 | 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-08-25 | — | — | US | disclosed |
| US-9359391-B2 | Selective C—O bond cleavage of oxidized lignin and lignin-type materials into simple aromatic compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2016-06-07 | — | — | US | disclosed |
| EP-2999701-A1 | 2-PHENYLIMIDAZO[1,2-A]PYRIMIDINES AS IMAGING AGENTS | Hoffmann-La Roche Inc. (US) | 2016-03-30 | — | — | EP | disclosed |
| EP-2991983-A1 | 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-03-09 | — | — | EP | disclosed |
| US-20150259368-A1 | SELECTIVE C-O BOND CLEAVAGE OF OXIDIZED LIGNIN AND LIGNIN-TYPE MATERIALS INTO SIMPLE AROMATIC COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2015-09-17 | — | — | US | disclosed |
| US-8969534-B2 | Selective aerobic alcohol oxidation method for conversion of lignin into simple aromatic compounds | Wisconsin Alumni Research Foundataion (US) | 2015-03-03 | — | — | US | disclosed |
| WO-2014177458-A1 | 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-11-06 | — | — | WO | disclosed |
| US-20140235838-A1 | SELECTIVE AEROBIC ALCOHOL OXIDATION METHOD FOR CONVERSION OF LIGNIN INTO SIMPLE AROMATIC COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259368-A1 | SELECTIVE C-O BOND CLEAVAGE OF OXIDIZED LIGNIN AND LIGNIN-TYPE MATERIALS INTO SIMPLE AROMATIC COMPOUNDS | AOC2, AOX1, AOC3 | GSK3B 3206/4885CTNNB1 3036/4885WNT3A 4164/4885 |
| US-20190048003-A1 | 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES | HTR3D, GDI2, GDI1 | GSK3B 4403/4885CTNNB1 3553/4885WNT3A 2832/4885 |
| US-10975073-B2 | Imaging methods using 2-hetaryl imidazol[1,2-a]pyridine derivatives | HTR3D, PTGDR2, PTGIR | GSK3B 4244/4885CTNNB1 3012/4885WNT3A 1678/4885 |
| US-10138234-B2 | 2-phenyl or 2-hetaryl imidazol[1,2-a]pyridine derivatives | CNKSR1, HCAR3, HCAR1 | GSK3B 4112/4885CTNNB1 2832/4885WNT3A 1516/4885 |
| US-20170128598-A1 | 2-PHENYLIMIDAZO[1,2-A]PYRIMIDINES AS IMAGING AGENTS | MAPT, AOC2, AOC3 | GSK3B 1795/4885CTNNB1 772/4885WNT3A 1823/4885 |
| US-20160244441-A1 | 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES | HTT, HCAR2, HCAR3 | GSK3B 3680/4885CTNNB1 3029/4885WNT3A 4135/4885 |
| US-20190048002-A1 | 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES | HTR3D, GDI2, GDI1 | GSK3B 4403/4885CTNNB1 3553/4885WNT3A 2832/4885 |
| US-11358962-B2 | 2-hetaryl imidazol[1,2-a]pyridine derivatives | TBXA2R, HRH2, CYP4F3 | GSK3B 4628/4885CTNNB1 4475/4885WNT3A 3126/4885 |
| US-11147884-B2 | Inhibitors of NHE-mediated antiport | SLC10A1, SLC10A2, SLC9A2 | GSK3B 2544/4885CTNNB1 1931/4885WNT3A 3041/4885 |
| US-20140235838-A1 | SELECTIVE AEROBIC ALCOHOL OXIDATION METHOD FOR CONVERSION OF LIGNIN INTO SIMPLE AROMATIC COMPOUNDS | AOX1, SOD1, NOX4 | GSK3B 4653/4885CTNNB1 3148/4885WNT3A 3719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.