SCHEMBL16132736

SCHEMBL16132736

CC(C)CC(=O)ON1C(=O)C=CC1=O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2C19 P33261 2/20 0.39
BLM P54132 2/20 0.39
HPGD P15428 1/20 0.39
WRN Q14191 1/20 0.39
HIF1A Q16665 1/20 0.39
GSK3A P49840 1/20 0.38
GSK3B P49841 1/20 0.38
MMP1 P03956 1/20 0.36
MMP2 P08253 1/20 0.36
MMP3 P08254 1/20 0.36
MMP9 P14780 1/20 0.36
MMP13 P45452 1/20 0.36
ALOX15 P16050 1/20 0.36
MIF P14174 1/20 0.35
MAPT P10636 2/20 0.33
TDP1 Q9NUW8 1/20 0.33
CYP2C9 P11712 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL558062 0.78 ALDH1A1 (0.57) ALDH1A1CYP1A2CYP2C19BLMHPGD
SCHEMBL11510545 0.78 CYP1A2 (0.34) ALDH1A1CYP1A2CYP2C19BLMHPGD
SCHEMBL2581743 0.77 ALDH1A1 (0.41) ALDH1A1CYP1A2CYP2C19BLMHPGD
SCHEMBL269178 0.77 ALDH1A1 (0.41) ALDH1A1CYP1A2CYP2C19BLMHPGD
SCHEMBL1245548 0.77 MMP1 (0.36) ALDH1A1MMP1MMP2MMP3MMP9
SCHEMBL20934272 0.76 PTGS1 (0.36) ALDH1A1CYP1A2CYP2C19BLMHPGD
SCHEMBL28981237 0.76 ALDH1A1 (0.55) ALDH1A1CYP1A2CYP2C19BLMHPGD
SCHEMBL31463689 0.75 ALDH1A1 (0.47) ALDH1A1CYP1A2CYP2C19MAPTCYP2C9
SCHEMBL714989 0.74 ALDH1A1 (0.44) ALDH1A1CYP1A2CYP2C19BLMHPGD
SCHEMBL1564922 0.74 CYP2D6 (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10576164-B2 Pyrrolobenzodiazepines and conjugates thereof MEDIMMUNE LIMITED (GB) 2020-03-03 US disclosed
US-20190247510-A1 DLL3 MODULATORS AND METHODS OF USE ABBVIE STEMCENTRX LLC (US) 2019-08-15 US disclosed
US-20190070305-A1 BENZODIAZEPINES AND CONJUGATES THEREOF IMMUNOGEN, INC. 2019-03-07 US disclosed
US-20190000969-A1 NOVEL ANTI-UPK1B ANTIBODIES AND METHODS OF USE ABBVIE STEMCENTRX LLC (US) 2019-01-03 US disclosed
US-20180125997-A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF MEDIMMUNE LIMITED (GB) 2018-05-10 US disclosed
US-9821074-B2 Pyrrolobenzodiazepines and conjugates thereof GENENTECH, INC. (US) 2017-11-21 US disclosed
US-20170266312-A1 ANTI-DLL3 ANTIBODY DRUG CONJUGATES ABBVIE STEMCENTRX LLC (US) 2017-09-21 US disclosed
US-20170266312-A1 ANTI-DLL3 ANTIBODY DRUG CONJUGATES ABBVIE STEMCENTRX LLC (US) 2017-09-21 US disclosed
US-20170239365-A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF MEDIMMUNE LIMITED (GB) 2017-08-24 US disclosed
US-9649390-B2 Pyrrolobenzodiazepines and conjugates thereof MEDIMMUNE LIMITED (GB) 2017-05-16 US disclosed
US-9555125-B2 Benzodiazepines and conjugates thereof IMMUNOGEN, INC. (US) 2017-01-31 US disclosed
US-20170000901-A1 DLL3 MODULATORS AND METHODS OF USE ABBVIE STEMCENTRX LLC (US) 2017-01-05 US disclosed
US-20160175460-A1 ENGINEERED ANTI-DLL3 CONJUGATES AND METHODS OF USE STEMCENTRX, INC. (US) 2016-06-23 US disclosed
US-20160144052-A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF SPIROGEN LIMITED (GB) 2016-05-26 US disclosed
US-20160075779-A1 DLL3 MODULATORS AND METHODS OF USE STEMCENTRX, INC. (US) 2016-03-17 US disclosed
US-20160031887-A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF SPIROGEN LIMITED (GB) 2016-02-04 US disclosed
US-9155803-B1 Anti-DLL3 antibody drug conjugates and methods of use STEMCENTRX, INC. (US) 2015-10-13 US disclosed
US-20150209444-A1 BENZODIAZEPINES AND CONJUGATES THEREOF IMMUNOGEN, INC. (US) 2015-07-30 US disclosed
US-20140294868-A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF MEDIMMUNE LIMITED (GB) 2014-10-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160144052-A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF CD79B, BCR, GABRA3 ALDH1A1 738/4885CYP1A2 111/4885CYP2C19 43/4885
US-20170000901-A1 DLL3 MODULATORS AND METHODS OF USE DLK1, PDLIM5, PDCD1LG2 ALDH1A1 3680/4885CYP1A2 4881/4885CYP2C19 4884/4885
US-10576164-B2 Pyrrolobenzodiazepines and conjugates thereof CHRM1, NPSR1, CHRM4 ALDH1A1 1949/4885CYP1A2 1039/4885CYP2C19 1092/4885
US-20150209444-A1 BENZODIAZEPINES AND CONJUGATES THEREOF GABBR1, GABRA1, GABBR2 ALDH1A1 246/4885CYP1A2 177/4885CYP2C19 121/4885
US-20140294868-A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF CHRM1, CHRM4, CHRM2 ALDH1A1 2065/4885CYP1A2 1013/4885CYP2C19 1105/4885
US-20160175460-A1 ENGINEERED ANTI-DLL3 CONJUGATES AND METHODS OF USE DYNLL1, DLK1, DYNLL2 ALDH1A1 979/4885CYP1A2 4843/4885CYP2C19 4853/4885
US-20180125997-A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF CHRM1, NPSR1, CHRM4 ALDH1A1 1940/4885CYP1A2 1033/4885CYP2C19 1092/4885
US-20190247510-A1 DLL3 MODULATORS AND METHODS OF USE DLK1, PDLIM5, PDCD1LG2 ALDH1A1 3680/4885CYP1A2 4881/4885CYP2C19 4884/4885
US-20160075779-A1 DLL3 MODULATORS AND METHODS OF USE DLK1, PDLIM5, PDCD1LG2 ALDH1A1 3680/4885CYP1A2 4881/4885CYP2C19 4884/4885
US-20170266312-A1 ANTI-DLL3 ANTIBODY DRUG CONJUGATES DLK1, DYNLL1, DYNLL2 ALDH1A1 2158/4885CYP1A2 4748/4885CYP2C19 4867/4885
US-20170239365-A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF CD79B, BOD1L1, GABRA1 ALDH1A1 974/4885CYP1A2 2715/4885CYP2C19 2352/4885
US-20190070305-A1 BENZODIAZEPINES AND CONJUGATES THEREOF GABBR1, GABRA1, GABBR2 ALDH1A1 246/4885CYP1A2 177/4885CYP2C19 121/4885
US-20190000969-A1 NOVEL ANTI-UPK1B ANTIBODIES AND METHODS OF USE UCK2, DCK, TTBK1 ALDH1A1 3426/4885CYP1A2 4865/4885CYP2C19 4878/4885
US-20160031887-A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF GABRA3, GABRA4, AVPR1B ALDH1A1 450/4885CYP1A2 64/4885CYP2C19 22/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.